Cargando…

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells

Dysfunction of interleukin-10 producing regulatory B cells has been associated with the pathogenesis of autoimmune diseases, but whether regulatory B cells can be therapeutically induced in humans is currently unknown. Here we demonstrate that a subset of activated B cells expresses CD25, and the ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inaba, Akimichi, Tuong, Zewen Kelvin, Zhao, Tian X., Stewart, Andrew P., Mathews, Rebeccah, Truman, Lucy, Sriranjan, Rouchelle, Kennet, Jane, Saeb-Parsy, Kourosh, Wicker, Linda, Waldron-Lynch, Frank, Cheriyan, Joseph, Todd, John A., Mallat, Ziad, Clatworthy, Menna R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097719/ https://www.ncbi.nlm.nih.gov/pubmed/37045832 http://dx.doi.org/10.1038/s41467-023-37424-w

Ejemplares similares

B Lymphocyte–Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury
por: Inaba, Akimichi, et al.
Publicado: (2020)

Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes
por: Lok, Laurence S. C., et al.
Publicado: (2019)

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease
por: Segal, Benjamin M., et al.
Publicado: (1998)

Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence
por: Riding, Alexandra M., et al.
Publicado: (2022)

Immunoregulatory Functions of the IL-12 Family of Cytokines in Antiviral Systems
por: Guo, Yifei, et al.
Publicado: (2019)

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study
por: Truman, Lucy A, et al.
Publicado: (2015)

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
por: Castro-Dopico, Tomas, et al.
Publicado: (2019)

IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets
por: Laroni, Alice, et al.
Publicado: (2011)

Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1
por: Casu, Beatrice, et al.
Publicado: (2019)

Bioengineering solutions for ureteric disorders: clinical need, challenges and opportunities
por: Kapetanos, Konstantinos, et al.
Publicado: (2022)

Low-dose IL-2 reduces IL-21(+) T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
por: Zhang, Jia-Yuan, et al.
Publicado: (2022)

Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial
por: Sriranjan, Rouchelle, et al.
Publicado: (2022)

BiP may have an immunoregulatory function mediated through IL-10 production
por: Corrigall, VM, et al.
Publicado: (2002)

Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction
por: Yu, Xian, et al.
Publicado: (2021)

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation
por: Castro-Dopico, Tomas, et al.
Publicado: (2020)

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes
por: Clatworthy, Menna R., et al.
Publicado: (2014)

Functional evaluation of immunoregulatory molecules HLA-G, galectin-1, and IL-10 in people living with HIV
por: Cortelette, Natalia Alves, et al.
Publicado: (2022)

Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies
por: Bareham, Bethany, et al.
Publicado: (2021)

Contrasting genetic association of IL2RA with SLE and ANCA – associated vasculitis
por: Carr, Edward J, et al.
Publicado: (2009)

The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide
por: Shaim, Hila, et al.
Publicado: (2018)

IL4‐10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10
por: Steen‐Louws, C., et al.
Publicado: (2018)

Abstract 113: Type-1 Interferons Impair The Immunoregulatory Activity Of IL-10: Understanding The Mechanisms Of Abrogation Of Transplant Tolerance
por: Iglesias, Marcos, et al.
Publicado: (2019)

IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule
por: Tabares-Guevara, Jorge H., et al.
Publicado: (2021)

Mesothelioma with non-pleural malignancy: a red herring or just an uncommon pairing?
por: Drain, Andrew J, et al.
Publicado: (2006)

Pancreatic allograft thrombosis: Suggestion for a CT grading system and management algorithm
por: Hakeem, A., et al.
Publicado: (2017)

Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant
por: Harper, Ines G., et al.
Publicado: (2016)

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
por: Jing, Chenzhi, et al.
Publicado: (2020)

Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice
por: Vazquez-Mateo, Cristina, et al.
Publicado: (2017)

Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation
por: Hosgood, Sarah A, et al.
Publicado: (2017)

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury
por: Martin, Jack L., et al.
Publicado: (2018)

Immunological considerations and challenges for regenerative cellular therapies
por: Petrus-Reurer, Sandra, et al.
Publicado: (2021)

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment
por: Ferreira, Ricardo C., et al.
Publicado: (2017)

An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1
por: Castellano, Flavia, et al.
Publicado: (2017)

Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype
por: Krakow, Sören, et al.
Publicado: (2019)

Synergism therapeutic and immunoregulatory effects of Albendazole + rAd-mIL-28B against Echinococcosis in experiment-infected mice with protoscoleces
por: Zhang, Yan, et al.
Publicado: (2021)

Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
por: Zhou, Chenhao, et al.
Publicado: (2019)

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ
por: Dare, Anna J., et al.
Publicado: (2015)

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
por: Neves, Fabiana, et al.
Publicado: (2015)

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial
por: Waldron-Lynch, Frank, et al.
Publicado: (2014)

IL22 Regulates Human Urothelial Cell Sensory and Innate Functions through Modulation of the Acetylcholine Response, Immunoregulatory Cytokines and Antimicrobial Peptides: Assessment of an In Vitro Model
por: Le, Phong T., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cu3b5prhildbljm3sd9jd1qn5j