Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity

Uncarialines A-E (1–5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1–3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold origin...

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Detalles Bibliográficos
Autores principales: Huang, Ke-Pu, Xu, Li-Li, Li, Sheng, Wei, Yin-Ling, Yang, Lian, Hao, Xiao-Jiang, He, Hong-Ping, Zhang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097851/
https://www.ncbi.nlm.nih.gov/pubmed/37043142
http://dx.doi.org/10.1007/s13659-023-00377-0
Descripción
Sumario:Uncarialines A-E (1–5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1–3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p < 0.001). GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00377-0.

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