Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models

The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies. Here, using epithelial cell adhesion molecule (EpCAM) as a model an...

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Detalles Bibliográficos
Autores principales: Yang, Yanping, Yang, Huan, Alcaina, Yago, Puc, Janusz, Birt, Alyssa, Vedvyas, Yogindra, Gallagher, Michael, Alla, Srinija, Riascos, Maria Cristina, McCloskey, Jaclyn E., Du, Karrie, Gonzalez-Valdivieso, Juan, Min, Irene M., de Stanchina, Elisa, Britz, Matt, von Hofe, Eric, Jin, Moonsoo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097865/
https://www.ncbi.nlm.nih.gov/pubmed/37045815
http://dx.doi.org/10.1038/s41467-023-37646-y

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