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Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage

INTRODUCTION: Endothelial nitric oxide synthase (eNOS) uncoupling plays a significant role in acute vasoconstriction during early brain injury (EBI) after subarachnoid hemorrhage (SAH). Astrocytes in the neurovascular unit extend their foot processes around endothelia. In our study, we tested the hy...

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Detalles Bibliográficos
Autores principales: Miao, Shu-Hao, Gao, Sheng-Qing, Li, Hui-Xin, Zhuang, Yun-Song, Wang, Xue, Li, Tao, Gao, Chao-Chao, Han, Yan-Ling, Qiu, Jia-Yin, Zhou, Meng-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097896/
https://www.ncbi.nlm.nih.gov/pubmed/37063365
http://dx.doi.org/10.3389/fnmol.2023.1121944