LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons

It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jiménez-Moreno et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain tran...

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Autores principales: Kournoutis, Athanasios, Johansen, Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097974/
https://www.ncbi.nlm.nih.gov/pubmed/37036692
http://dx.doi.org/10.1083/jcb.202303008
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author Kournoutis, Athanasios
Johansen, Terje
author_facet Kournoutis, Athanasios
Johansen, Terje
author_sort Kournoutis, Athanasios
collection PubMed
description It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jiménez-Moreno et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for LMX1B-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons.
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spelling pubmed-100979742023-10-10 LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons Kournoutis, Athanasios Johansen, Terje J Cell Biol Spotlight It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jiménez-Moreno et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for LMX1B-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons. Rockefeller University Press 2023-04-10 /pmc/articles/PMC10097974/ /pubmed/37036692 http://dx.doi.org/10.1083/jcb.202303008 Text en © 2023 Kournoutis and Johansen https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Kournoutis, Athanasios
Johansen, Terje
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title_full LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title_fullStr LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title_full_unstemmed LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title_short LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
title_sort lc3b is a cofactor for lmx1b-mediated transcription of autophagy genes in dopaminergic neurons
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097974/
https://www.ncbi.nlm.nih.gov/pubmed/37036692
http://dx.doi.org/10.1083/jcb.202303008
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