Cargando…

Associations of parental reproductive age and elevated blood pressure in offspring: An observational study

BACKGROUND: Increased parental reproductive age has been a social trend around the world, and elevated blood pressure in children leads to an approximately two-fold increased risk of hypertension in adulthood. Aim of this study is to assess the associations of parental reproductive age with the risk...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Rui, Lou, Ke, Zhou, Siliang, Li, Xingxiu, Dong, Bin, Ma, Jun, Hu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098010/
https://www.ncbi.nlm.nih.gov/pubmed/37063654
http://dx.doi.org/10.3389/fped.2023.990725
_version_ 1785024698386481152
author Deng, Rui
Lou, Ke
Zhou, Siliang
Li, Xingxiu
Dong, Bin
Ma, Jun
Hu, Jie
author_facet Deng, Rui
Lou, Ke
Zhou, Siliang
Li, Xingxiu
Dong, Bin
Ma, Jun
Hu, Jie
author_sort Deng, Rui
collection PubMed
description BACKGROUND: Increased parental reproductive age has been a social trend around the world, and elevated blood pressure in children leads to an approximately two-fold increased risk of hypertension in adulthood. Aim of this study is to assess the associations of parental reproductive age with the risk of elevated blood pressure in offspring, and to explore the influence of offspring lifestyle on the associations. METHODS: Data was obtained from a national school program conducted in 7 Chinese provinces, and the final sample was 39,190 students aged 7–18 years. Anthropometric measurements and questionnaires were designed to collect data of children blood pressure and information respectively. RESULTS: In this study, 26.7% of children were defined as elevated blood pressure. A U-shaped pattern was observed in the relationship between maternal age and risk of elevated blood pressure, while risk of elevated blood pressure decreased continuously with paternal age increased. After adjustment, offspring of paternal age ≤27 & maternal age ≤26 years and those of paternal age >30 & maternal age >32 years were related to great risk of elevated blood pressure (OR = 1.18, 95% CI: 1.08–1.29, P < 0.001; OR = 1.18, 95% CI: 1.01–1.38, P < 0.05). When stratified by lifestyle status, significant associations between maternal/paternal age and risk of elevated blood pressure were only observed in those with worse lifestyle behaviors, but not in offspring with healthier lifestyle. CONCLUSION: Our findings demonstrate that risk of elevated blood pressure in children is independently related to parental reproductive age, and children maintaining a healthy lifestyle may mitigate the adverse effect.
format Online
Article
Text
id pubmed-10098010
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100980102023-04-14 Associations of parental reproductive age and elevated blood pressure in offspring: An observational study Deng, Rui Lou, Ke Zhou, Siliang Li, Xingxiu Dong, Bin Ma, Jun Hu, Jie Front Pediatr Pediatrics BACKGROUND: Increased parental reproductive age has been a social trend around the world, and elevated blood pressure in children leads to an approximately two-fold increased risk of hypertension in adulthood. Aim of this study is to assess the associations of parental reproductive age with the risk of elevated blood pressure in offspring, and to explore the influence of offspring lifestyle on the associations. METHODS: Data was obtained from a national school program conducted in 7 Chinese provinces, and the final sample was 39,190 students aged 7–18 years. Anthropometric measurements and questionnaires were designed to collect data of children blood pressure and information respectively. RESULTS: In this study, 26.7% of children were defined as elevated blood pressure. A U-shaped pattern was observed in the relationship between maternal age and risk of elevated blood pressure, while risk of elevated blood pressure decreased continuously with paternal age increased. After adjustment, offspring of paternal age ≤27 & maternal age ≤26 years and those of paternal age >30 & maternal age >32 years were related to great risk of elevated blood pressure (OR = 1.18, 95% CI: 1.08–1.29, P < 0.001; OR = 1.18, 95% CI: 1.01–1.38, P < 0.05). When stratified by lifestyle status, significant associations between maternal/paternal age and risk of elevated blood pressure were only observed in those with worse lifestyle behaviors, but not in offspring with healthier lifestyle. CONCLUSION: Our findings demonstrate that risk of elevated blood pressure in children is independently related to parental reproductive age, and children maintaining a healthy lifestyle may mitigate the adverse effect. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10098010/ /pubmed/37063654 http://dx.doi.org/10.3389/fped.2023.990725 Text en © 2023 Deng, Lou, Zhou, Li, Dong, Ma and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Deng, Rui
Lou, Ke
Zhou, Siliang
Li, Xingxiu
Dong, Bin
Ma, Jun
Hu, Jie
Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title_full Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title_fullStr Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title_full_unstemmed Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title_short Associations of parental reproductive age and elevated blood pressure in offspring: An observational study
title_sort associations of parental reproductive age and elevated blood pressure in offspring: an observational study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098010/
https://www.ncbi.nlm.nih.gov/pubmed/37063654
http://dx.doi.org/10.3389/fped.2023.990725
work_keys_str_mv AT dengrui associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT louke associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT zhousiliang associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT lixingxiu associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT dongbin associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT majun associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy
AT hujie associationsofparentalreproductiveageandelevatedbloodpressureinoffspringanobservationalstudy