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Fungal alkaline proteases and their potential applications in different industries

The consumption of various enzymes in industrial applications around the world has increased immensely. Nowadays, industries are more focused on incorporating microbial enzymes in multiple processes to avoid the hazardous effects of chemicals. Among these commercially exploited enzymes, proteases ar...

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Autores principales: Pawar, Kadambari Subhash, Singh, Paras Nath, Singh, Sanjay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098022/
https://www.ncbi.nlm.nih.gov/pubmed/37065163
http://dx.doi.org/10.3389/fmicb.2023.1138401
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author Pawar, Kadambari Subhash
Singh, Paras Nath
Singh, Sanjay Kumar
author_facet Pawar, Kadambari Subhash
Singh, Paras Nath
Singh, Sanjay Kumar
author_sort Pawar, Kadambari Subhash
collection PubMed
description The consumption of various enzymes in industrial applications around the world has increased immensely. Nowadays, industries are more focused on incorporating microbial enzymes in multiple processes to avoid the hazardous effects of chemicals. Among these commercially exploited enzymes, proteases are the most abundantly used enzymes in different industries. Numerous bacterial alkaline proteases have been studied widely and are commercially available; however, fungi exhibit a broader variety of proteases than bacteria. Additionally, since fungi are often recognized as generally regarded as safe (GRAS), using them as enzyme producers is safer than using bacteria. Fungal alkaline proteases are appealing models for industrial use because of their distinct spectrum of action and enormous diversity in terms of being active under alkaline range of pH. Unlike bacteria, fungi are less studied for alkaline protease production. Moreover, group of fungi growing at alkaline pH has remained unexplored for their capability for the production of commercially valuable products that are stable at alkaline pH. The current review focuses on the detailed classification of proteases, the production of alkaline proteases from different fungi by fermentation (submerged and solid–state), and their potential applications in detergent, leather, food, pharmaceutical industries along with their important role in silk degumming, waste management and silver recovery processes. Furthermore, the promising role of alkali–tolerant and alkaliphilic fungi in enzyme production has been discussed briefly. This will highlight the need for more research on fungi growing at alkaline pH and their biotechnological potential.
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spelling pubmed-100980222023-04-14 Fungal alkaline proteases and their potential applications in different industries Pawar, Kadambari Subhash Singh, Paras Nath Singh, Sanjay Kumar Front Microbiol Microbiology The consumption of various enzymes in industrial applications around the world has increased immensely. Nowadays, industries are more focused on incorporating microbial enzymes in multiple processes to avoid the hazardous effects of chemicals. Among these commercially exploited enzymes, proteases are the most abundantly used enzymes in different industries. Numerous bacterial alkaline proteases have been studied widely and are commercially available; however, fungi exhibit a broader variety of proteases than bacteria. Additionally, since fungi are often recognized as generally regarded as safe (GRAS), using them as enzyme producers is safer than using bacteria. Fungal alkaline proteases are appealing models for industrial use because of their distinct spectrum of action and enormous diversity in terms of being active under alkaline range of pH. Unlike bacteria, fungi are less studied for alkaline protease production. Moreover, group of fungi growing at alkaline pH has remained unexplored for their capability for the production of commercially valuable products that are stable at alkaline pH. The current review focuses on the detailed classification of proteases, the production of alkaline proteases from different fungi by fermentation (submerged and solid–state), and their potential applications in detergent, leather, food, pharmaceutical industries along with their important role in silk degumming, waste management and silver recovery processes. Furthermore, the promising role of alkali–tolerant and alkaliphilic fungi in enzyme production has been discussed briefly. This will highlight the need for more research on fungi growing at alkaline pH and their biotechnological potential. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10098022/ /pubmed/37065163 http://dx.doi.org/10.3389/fmicb.2023.1138401 Text en Copyright © 2023 Pawar, Singh and Singh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Pawar, Kadambari Subhash
Singh, Paras Nath
Singh, Sanjay Kumar
Fungal alkaline proteases and their potential applications in different industries
title Fungal alkaline proteases and their potential applications in different industries
title_full Fungal alkaline proteases and their potential applications in different industries
title_fullStr Fungal alkaline proteases and their potential applications in different industries
title_full_unstemmed Fungal alkaline proteases and their potential applications in different industries
title_short Fungal alkaline proteases and their potential applications in different industries
title_sort fungal alkaline proteases and their potential applications in different industries
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098022/
https://www.ncbi.nlm.nih.gov/pubmed/37065163
http://dx.doi.org/10.3389/fmicb.2023.1138401
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