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High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022
Human papilloma virus (HPV) infection and its associated disease are major problems affecting millions of individuals around the world. The distribution of HPV genotypes is specific to different areas and different populations. Therefore, understanding the prevalence and genotype distribution of HPV...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098111/ https://www.ncbi.nlm.nih.gov/pubmed/37064671 http://dx.doi.org/10.3389/fpubh.2023.1145396 |
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author | Zheng, Li-li Chen, Shuang-feng Yang, Fei Wang, Wei-hua Xu, Cong Zheng, Li-yuan |
author_facet | Zheng, Li-li Chen, Shuang-feng Yang, Fei Wang, Wei-hua Xu, Cong Zheng, Li-yuan |
author_sort | Zheng, Li-li |
collection | PubMed |
description | Human papilloma virus (HPV) infection and its associated disease are major problems affecting millions of individuals around the world. The distribution of HPV genotypes is specific to different areas and different populations. Therefore, understanding the prevalence and genotype distribution of HPV in different populations in different geographical regions is essential to optimize HPV vaccination strategies and to maximize vaccine effects. In this study, 34,076 women from January 2016 to July 2022 were retrospectively analyzed at Liaocheng People's Hospital. Of these, 7540 women were high-risk HPV positive and the infection rate was 22.13%. The top ten genotypes were as follows in descending order: HPV16, HPV52, HPV58, HPV53, HPV39, HPV59, HPV66, HPV51, HPV18, and HPV56 and the least frequent genotypes were, in order, HPV 26, HPV45, and HPV82. The HPV16 positive infection rate was 25.37% and was reduced with the increase in the number of individuals who had undergone HPV screening. The HPV52 infection rate increased with increasing numbers of individuals undergoing HPV screening, and then remained unchanged. The proportion of 20–29-year-olds among all positive women began to decrease since the vaccine was available in 2018. The 30–39-year-old group accounted for the highest percentage of positive women, and the 50–59-year-old group of HPV-positive women with cervical cancer accounted for most infections. This study confirmed that HPV16, HPV52, HPV 58, and HPV53 is widely distributed in this population and the total HR-HPV infection rate remains high in this region. Our findings indicate that prevention of HPV infection in this region still faces important challenges. |
format | Online Article Text |
id | pubmed-10098111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100981112023-04-14 High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 Zheng, Li-li Chen, Shuang-feng Yang, Fei Wang, Wei-hua Xu, Cong Zheng, Li-yuan Front Public Health Public Health Human papilloma virus (HPV) infection and its associated disease are major problems affecting millions of individuals around the world. The distribution of HPV genotypes is specific to different areas and different populations. Therefore, understanding the prevalence and genotype distribution of HPV in different populations in different geographical regions is essential to optimize HPV vaccination strategies and to maximize vaccine effects. In this study, 34,076 women from January 2016 to July 2022 were retrospectively analyzed at Liaocheng People's Hospital. Of these, 7540 women were high-risk HPV positive and the infection rate was 22.13%. The top ten genotypes were as follows in descending order: HPV16, HPV52, HPV58, HPV53, HPV39, HPV59, HPV66, HPV51, HPV18, and HPV56 and the least frequent genotypes were, in order, HPV 26, HPV45, and HPV82. The HPV16 positive infection rate was 25.37% and was reduced with the increase in the number of individuals who had undergone HPV screening. The HPV52 infection rate increased with increasing numbers of individuals undergoing HPV screening, and then remained unchanged. The proportion of 20–29-year-olds among all positive women began to decrease since the vaccine was available in 2018. The 30–39-year-old group accounted for the highest percentage of positive women, and the 50–59-year-old group of HPV-positive women with cervical cancer accounted for most infections. This study confirmed that HPV16, HPV52, HPV 58, and HPV53 is widely distributed in this population and the total HR-HPV infection rate remains high in this region. Our findings indicate that prevention of HPV infection in this region still faces important challenges. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10098111/ /pubmed/37064671 http://dx.doi.org/10.3389/fpubh.2023.1145396 Text en Copyright © 2023 Zheng, Chen, Yang, Wang, Xu and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Zheng, Li-li Chen, Shuang-feng Yang, Fei Wang, Wei-hua Xu, Cong Zheng, Li-yuan High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title | High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title_full | High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title_fullStr | High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title_full_unstemmed | High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title_short | High-risk HPV prevalence and genotype distribution among women in Liaocheng, Shandong Province, China from 2016 to 2022 |
title_sort | high-risk hpv prevalence and genotype distribution among women in liaocheng, shandong province, china from 2016 to 2022 |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098111/ https://www.ncbi.nlm.nih.gov/pubmed/37064671 http://dx.doi.org/10.3389/fpubh.2023.1145396 |
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