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Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study
Identification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cog...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098130/ https://www.ncbi.nlm.nih.gov/pubmed/37065459 http://dx.doi.org/10.3389/fnagi.2023.1125114 |
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author | Mahoney, Jeannette R. Blumen, Helena M. De Sanctis, Pierfilippo Fleysher, Roman Frankini, Carolina Hoang, Alexandria Hoptman, Matthew J. Jin, Runqiu Lipton, Michael Nunez, Valerie Twizer, Lital Uy, Naomi Valdivia, Ana Verghese, Tanya Wang, Cuiling Weiss, Erica F. Zwerling, Jessica Verghese, Joe |
author_facet | Mahoney, Jeannette R. Blumen, Helena M. De Sanctis, Pierfilippo Fleysher, Roman Frankini, Carolina Hoang, Alexandria Hoptman, Matthew J. Jin, Runqiu Lipton, Michael Nunez, Valerie Twizer, Lital Uy, Naomi Valdivia, Ana Verghese, Tanya Wang, Cuiling Weiss, Erica F. Zwerling, Jessica Verghese, Joe |
author_sort | Mahoney, Jeannette R. |
collection | PubMed |
description | Identification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cognitive functions, such as memory. Previous investigations have not comprehensively examined the interplay of sensory, cognitive, and motor dysfunction with relation to AD progression. The ability to successfully integrate multisensory information across multiple sensory modalities is a vital aspect of everyday functioning and mobility. Our research suggests that multisensory integration, specifically visual-somatosensory integration (VSI), could be used as a novel marker for preclinical AD given previously reported associations with important motor (balance, gait, and falls) and cognitive (attention) outcomes in aging. While the adverse effect of dementia and cognitive impairment on the relationship between multisensory functioning and motor outcomes has been highlighted, the underlying functional and neuroanatomical networks are still unknown. In what follows we detail the protocol for our study, named The VSI Study, which is strategically designed to determine whether preclinical AD is associated with neural disruptions in subcortical and cortical areas that concurrently modulate multisensory, cognitive, and motor functions resulting in mobility decline. In this longitudinal observational study, a total of 208 community-dwelling older adults with and without preclinical AD will be recruited and monitored yearly. Our experimental design affords assessment of multisensory integration as a new behavioral marker for preclinical AD; identification of functional neural networks involved in the intersection of sensory, motor, and cognitive functioning; and determination of the impact of early AD on future mobility declines, including incident falls. Results of The VSI Study will guide future development of innovative multisensory-based interventions aimed at preventing disability and optimizing independence in pathological aging. |
format | Online Article Text |
id | pubmed-10098130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100981302023-04-14 Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study Mahoney, Jeannette R. Blumen, Helena M. De Sanctis, Pierfilippo Fleysher, Roman Frankini, Carolina Hoang, Alexandria Hoptman, Matthew J. Jin, Runqiu Lipton, Michael Nunez, Valerie Twizer, Lital Uy, Naomi Valdivia, Ana Verghese, Tanya Wang, Cuiling Weiss, Erica F. Zwerling, Jessica Verghese, Joe Front Aging Neurosci Neuroscience Identification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cognitive functions, such as memory. Previous investigations have not comprehensively examined the interplay of sensory, cognitive, and motor dysfunction with relation to AD progression. The ability to successfully integrate multisensory information across multiple sensory modalities is a vital aspect of everyday functioning and mobility. Our research suggests that multisensory integration, specifically visual-somatosensory integration (VSI), could be used as a novel marker for preclinical AD given previously reported associations with important motor (balance, gait, and falls) and cognitive (attention) outcomes in aging. While the adverse effect of dementia and cognitive impairment on the relationship between multisensory functioning and motor outcomes has been highlighted, the underlying functional and neuroanatomical networks are still unknown. In what follows we detail the protocol for our study, named The VSI Study, which is strategically designed to determine whether preclinical AD is associated with neural disruptions in subcortical and cortical areas that concurrently modulate multisensory, cognitive, and motor functions resulting in mobility decline. In this longitudinal observational study, a total of 208 community-dwelling older adults with and without preclinical AD will be recruited and monitored yearly. Our experimental design affords assessment of multisensory integration as a new behavioral marker for preclinical AD; identification of functional neural networks involved in the intersection of sensory, motor, and cognitive functioning; and determination of the impact of early AD on future mobility declines, including incident falls. Results of The VSI Study will guide future development of innovative multisensory-based interventions aimed at preventing disability and optimizing independence in pathological aging. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10098130/ /pubmed/37065459 http://dx.doi.org/10.3389/fnagi.2023.1125114 Text en Copyright © 2023 Mahoney, Blumen, De Sanctis, Fleysher, Frankini, Hoang, Hoptman, Jin, Lipton, Nunez, Twizer, Uy, Valdivia, Verghese, Wang, Weiss, Zwerling and Verghese. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Mahoney, Jeannette R. Blumen, Helena M. De Sanctis, Pierfilippo Fleysher, Roman Frankini, Carolina Hoang, Alexandria Hoptman, Matthew J. Jin, Runqiu Lipton, Michael Nunez, Valerie Twizer, Lital Uy, Naomi Valdivia, Ana Verghese, Tanya Wang, Cuiling Weiss, Erica F. Zwerling, Jessica Verghese, Joe Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title_full | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title_fullStr | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title_full_unstemmed | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title_short | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
title_sort | visual-somatosensory integration (vsi) as a novel marker of alzheimer’s disease: a comprehensive overview of the vsi study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098130/ https://www.ncbi.nlm.nih.gov/pubmed/37065459 http://dx.doi.org/10.3389/fnagi.2023.1125114 |
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