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Sex-related differences in endothelial function and blood viscosity in the elderly population
Elderly represents a growing population and cardiovascular diseases (CVD) is one of the leading causes of mortality in this population. Sex differences are involved in CVD with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098165/ https://www.ncbi.nlm.nih.gov/pubmed/37064903 http://dx.doi.org/10.3389/fphys.2023.1151088 |
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author | Raberin, Antoine Martin, Cyril Celle, Sébastien Hupin, David Roche, Frederic Barthelemy, Jean-Claude Connes, Philippe |
author_facet | Raberin, Antoine Martin, Cyril Celle, Sébastien Hupin, David Roche, Frederic Barthelemy, Jean-Claude Connes, Philippe |
author_sort | Raberin, Antoine |
collection | PubMed |
description | Elderly represents a growing population and cardiovascular diseases (CVD) is one of the leading causes of mortality in this population. Sex differences are involved in CVD with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the role of sex on cardiovascular parameters involved in CVD, such as endothelial function and blood viscosity, is still unclear. The purpose of this study was to investigate the effect of sex on endothelial function, blood viscosity and CVD in elderly. Clinical investigation and blood analyses were performed on 182 (93 females and 89 males) elderly participants (mean age: 75.83 ± 1.22). Health status of participants were classified. Sex differences in endothelial function, blood viscosity, high density lipoprotein (HDL), hematocrit, and red blood cell (RBC) aggregation were assessed. CVD prevalence was higher in males (27.0%) than in females (5.4%) (p < 0.001). Females had higher vasoreactivity (p = 0.014) and HDL (p < 0.001) level than males. Blood viscosity was higher in males than in females at any shear rate (p < 0.001). Hematocrit was greater in males than in females (p < 0.001) while RBC aggregation did not differ between the two populations. To conclude, females have less CVD than age-matched males that might be due to their greater vascular function and lower blood viscosity. |
format | Online Article Text |
id | pubmed-10098165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100981652023-04-14 Sex-related differences in endothelial function and blood viscosity in the elderly population Raberin, Antoine Martin, Cyril Celle, Sébastien Hupin, David Roche, Frederic Barthelemy, Jean-Claude Connes, Philippe Front Physiol Physiology Elderly represents a growing population and cardiovascular diseases (CVD) is one of the leading causes of mortality in this population. Sex differences are involved in CVD with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the role of sex on cardiovascular parameters involved in CVD, such as endothelial function and blood viscosity, is still unclear. The purpose of this study was to investigate the effect of sex on endothelial function, blood viscosity and CVD in elderly. Clinical investigation and blood analyses were performed on 182 (93 females and 89 males) elderly participants (mean age: 75.83 ± 1.22). Health status of participants were classified. Sex differences in endothelial function, blood viscosity, high density lipoprotein (HDL), hematocrit, and red blood cell (RBC) aggregation were assessed. CVD prevalence was higher in males (27.0%) than in females (5.4%) (p < 0.001). Females had higher vasoreactivity (p = 0.014) and HDL (p < 0.001) level than males. Blood viscosity was higher in males than in females at any shear rate (p < 0.001). Hematocrit was greater in males than in females (p < 0.001) while RBC aggregation did not differ between the two populations. To conclude, females have less CVD than age-matched males that might be due to their greater vascular function and lower blood viscosity. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10098165/ /pubmed/37064903 http://dx.doi.org/10.3389/fphys.2023.1151088 Text en Copyright © 2023 Raberin, Martin, Celle, Hupin, Roche, Barthelemy and Connes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Raberin, Antoine Martin, Cyril Celle, Sébastien Hupin, David Roche, Frederic Barthelemy, Jean-Claude Connes, Philippe Sex-related differences in endothelial function and blood viscosity in the elderly population |
title | Sex-related differences in endothelial function and blood viscosity in the elderly population |
title_full | Sex-related differences in endothelial function and blood viscosity in the elderly population |
title_fullStr | Sex-related differences in endothelial function and blood viscosity in the elderly population |
title_full_unstemmed | Sex-related differences in endothelial function and blood viscosity in the elderly population |
title_short | Sex-related differences in endothelial function and blood viscosity in the elderly population |
title_sort | sex-related differences in endothelial function and blood viscosity in the elderly population |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098165/ https://www.ncbi.nlm.nih.gov/pubmed/37064903 http://dx.doi.org/10.3389/fphys.2023.1151088 |
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