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Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancers

BACKGROUND: Our previous study showed that transmembrane tumor necrosis factor alpha (tmTNF-α) is overexpressed in primary breast cancers including triple-negative breast cancers (TNBCs). Chimeric antigen receptor engineered-T (CAR-T) cells have been successfully used mainly in B-cell malignancies....

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Detalles Bibliográficos
Autores principales:	Ba, Hongping, Dai, Zigang, Zhang, Zunyue, Zhang, Peng, Yin, Bingjiao, Wang, Jing, Li, Zhuoya, Zhou, Xiaoxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098269/ https://www.ncbi.nlm.nih.gov/pubmed/36720496 http://dx.doi.org/10.1136/jitc-2021-003837

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