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Effect of xylitol on Porphyromonas gingivalis: A systematic review

OBJECTIVE: This review was conducted to assess the effectiveness of xylitol against Porphyromonas gingivalis anaerobic species, a key microbe contributing to periodontal disease pathogenesis. MATERIAL AND METHODS: Relevant studies published on seven online databases (Cochrane, Ovid, Pubmed, Pubmed C...

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Autores principales: Chen, Sau You, Delacruz, Joshua, Kim, Yong, Kingston, Roger, Purvis, Laura, Sharma, Dileep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098279/
https://www.ncbi.nlm.nih.gov/pubmed/36894516
http://dx.doi.org/10.1002/cre2.724
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author Chen, Sau You
Delacruz, Joshua
Kim, Yong
Kingston, Roger
Purvis, Laura
Sharma, Dileep
author_facet Chen, Sau You
Delacruz, Joshua
Kim, Yong
Kingston, Roger
Purvis, Laura
Sharma, Dileep
author_sort Chen, Sau You
collection PubMed
description OBJECTIVE: This review was conducted to assess the effectiveness of xylitol against Porphyromonas gingivalis anaerobic species, a key microbe contributing to periodontal disease pathogenesis. MATERIAL AND METHODS: Relevant studies published on seven online databases (Cochrane, Ovid, Pubmed, Pubmed Central, Scopus, Google Scholar, and Web of Science) were included in accordance with the PRISMA guidelines. Inclusion criteria allowed all study designs involving xylitol and P. gingivalis, literature published since the year 2000, and all xylitol delivery forms. RESULTS: The initial search yielded 186 papers. After the removal of duplicates, five reviewers screened every article for eligibility and seven articles were selected for data extraction. Four out of seven included studies assessed the dose‐dependent effect of xylitol on P. gingivalis growth, two studies assessed the effect of xylitol on P. gingivalis‐induced cytokine expression, and one study assessed both domains. CONCLUSIONS: From the in vitro studies included in this systematic review, there is some evidence of xylitol's inhibitory effect on P. gingivalis. However, more evidence derived from in vivo studies is required to confirm its effectiveness warranting their routine use.
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spelling pubmed-100982792023-04-14 Effect of xylitol on Porphyromonas gingivalis: A systematic review Chen, Sau You Delacruz, Joshua Kim, Yong Kingston, Roger Purvis, Laura Sharma, Dileep Clin Exp Dent Res Review Article OBJECTIVE: This review was conducted to assess the effectiveness of xylitol against Porphyromonas gingivalis anaerobic species, a key microbe contributing to periodontal disease pathogenesis. MATERIAL AND METHODS: Relevant studies published on seven online databases (Cochrane, Ovid, Pubmed, Pubmed Central, Scopus, Google Scholar, and Web of Science) were included in accordance with the PRISMA guidelines. Inclusion criteria allowed all study designs involving xylitol and P. gingivalis, literature published since the year 2000, and all xylitol delivery forms. RESULTS: The initial search yielded 186 papers. After the removal of duplicates, five reviewers screened every article for eligibility and seven articles were selected for data extraction. Four out of seven included studies assessed the dose‐dependent effect of xylitol on P. gingivalis growth, two studies assessed the effect of xylitol on P. gingivalis‐induced cytokine expression, and one study assessed both domains. CONCLUSIONS: From the in vitro studies included in this systematic review, there is some evidence of xylitol's inhibitory effect on P. gingivalis. However, more evidence derived from in vivo studies is required to confirm its effectiveness warranting their routine use. John Wiley and Sons Inc. 2023-03-09 /pmc/articles/PMC10098279/ /pubmed/36894516 http://dx.doi.org/10.1002/cre2.724 Text en © 2023 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Sau You
Delacruz, Joshua
Kim, Yong
Kingston, Roger
Purvis, Laura
Sharma, Dileep
Effect of xylitol on Porphyromonas gingivalis: A systematic review
title Effect of xylitol on Porphyromonas gingivalis: A systematic review
title_full Effect of xylitol on Porphyromonas gingivalis: A systematic review
title_fullStr Effect of xylitol on Porphyromonas gingivalis: A systematic review
title_full_unstemmed Effect of xylitol on Porphyromonas gingivalis: A systematic review
title_short Effect of xylitol on Porphyromonas gingivalis: A systematic review
title_sort effect of xylitol on porphyromonas gingivalis: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098279/
https://www.ncbi.nlm.nih.gov/pubmed/36894516
http://dx.doi.org/10.1002/cre2.724
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