Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3

Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients with early breast cancer (BC), potentially setting the scene for more effective implementation of checkpoint-targeted immunotherapy. This issue has been investigated in the current study in which alterations in the plasma conc...

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Detalles Bibliográficos
Autores principales: Rapoport, Bernardo L., Steel, Helen C., Benn, Carol A., Nayler, Simon, Smit, Teresa, Heyman, Liezl, Theron, Annette J., Hlatshwayo, Nomsa, Kwofie, Luyanda L.I., Meyer, Pieter W.A., Anderson, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098332/
https://www.ncbi.nlm.nih.gov/pubmed/37064132
http://dx.doi.org/10.3389/fonc.2023.1097309

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