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Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outco...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098482/ https://www.ncbi.nlm.nih.gov/pubmed/36413694 http://dx.doi.org/10.1111/jocs.17145 |
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author | Khamees, Khalid Al Grasso, Elena Ibrahim, Ahmed Abdallah, Hassane Adbelhamed, Mohamad I. Sayin, Omer Lorusso, Roberto |
author_facet | Khamees, Khalid Al Grasso, Elena Ibrahim, Ahmed Abdallah, Hassane Adbelhamed, Mohamad I. Sayin, Omer Lorusso, Roberto |
author_sort | Khamees, Khalid Al |
collection | PubMed |
description | BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outcomes of LVAD implantation in patients with sickle‐cell hemoglobinopathy at our institution. METHODS: This retrospective, observational, single‐center study was conducted on patients with sickle‐cell trait (SCT), who underwent LVAD implantation using the HeartMate3 LVAD. RESULTS: LVAD devices were implanted in four patients with SCT. All procedures were performed successfully. All patients had uneventful post‐implant course. Overall, the mean follow‐up time was 25 months (range 21–28 months) and showed an unremarkable post‐implant course. There was a significant improvement in hematological markers over the follow‐up period. CONCLUSIONS: Despite the limited numbers of patients enrolled in this study, our findings indicate that LVAD surgery is safe in SCD patients and offers remarkable clinical improvement. Further studies are needed to provide more evidence regarding this type of patients undergoing LVAD implantation. |
format | Online Article Text |
id | pubmed-10098482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100984822023-04-14 Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis Khamees, Khalid Al Grasso, Elena Ibrahim, Ahmed Abdallah, Hassane Adbelhamed, Mohamad I. Sayin, Omer Lorusso, Roberto J Card Surg Regular Issue Papers BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outcomes of LVAD implantation in patients with sickle‐cell hemoglobinopathy at our institution. METHODS: This retrospective, observational, single‐center study was conducted on patients with sickle‐cell trait (SCT), who underwent LVAD implantation using the HeartMate3 LVAD. RESULTS: LVAD devices were implanted in four patients with SCT. All procedures were performed successfully. All patients had uneventful post‐implant course. Overall, the mean follow‐up time was 25 months (range 21–28 months) and showed an unremarkable post‐implant course. There was a significant improvement in hematological markers over the follow‐up period. CONCLUSIONS: Despite the limited numbers of patients enrolled in this study, our findings indicate that LVAD surgery is safe in SCD patients and offers remarkable clinical improvement. Further studies are needed to provide more evidence regarding this type of patients undergoing LVAD implantation. John Wiley and Sons Inc. 2022-11-22 2022-12 /pmc/articles/PMC10098482/ /pubmed/36413694 http://dx.doi.org/10.1111/jocs.17145 Text en © 2022 The Authors. Journal of Cardiac Surgery published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Issue Papers Khamees, Khalid Al Grasso, Elena Ibrahim, Ahmed Abdallah, Hassane Adbelhamed, Mohamad I. Sayin, Omer Lorusso, Roberto Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title | Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title_full | Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title_fullStr | Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title_full_unstemmed | Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title_short | Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis |
title_sort | single‐center experience of lvad implantation in patients with sickle‐cell trait: a retrospective analysis |
topic | Regular Issue Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098482/ https://www.ncbi.nlm.nih.gov/pubmed/36413694 http://dx.doi.org/10.1111/jocs.17145 |
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