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Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis

BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outco...

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Autores principales: Khamees, Khalid Al, Grasso, Elena, Ibrahim, Ahmed, Abdallah, Hassane, Adbelhamed, Mohamad I., Sayin, Omer, Lorusso, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098482/
https://www.ncbi.nlm.nih.gov/pubmed/36413694
http://dx.doi.org/10.1111/jocs.17145
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author Khamees, Khalid Al
Grasso, Elena
Ibrahim, Ahmed
Abdallah, Hassane
Adbelhamed, Mohamad I.
Sayin, Omer
Lorusso, Roberto
author_facet Khamees, Khalid Al
Grasso, Elena
Ibrahim, Ahmed
Abdallah, Hassane
Adbelhamed, Mohamad I.
Sayin, Omer
Lorusso, Roberto
author_sort Khamees, Khalid Al
collection PubMed
description BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outcomes of LVAD implantation in patients with sickle‐cell hemoglobinopathy at our institution. METHODS: This retrospective, observational, single‐center study was conducted on patients with sickle‐cell trait (SCT), who underwent LVAD implantation using the HeartMate3 LVAD. RESULTS: LVAD devices were implanted in four patients with SCT. All procedures were performed successfully. All patients had uneventful post‐implant course. Overall, the mean follow‐up time was 25 months (range 21–28 months) and showed an unremarkable post‐implant course. There was a significant improvement in hematological markers over the follow‐up period. CONCLUSIONS: Despite the limited numbers of patients enrolled in this study, our findings indicate that LVAD surgery is safe in SCD patients and offers remarkable clinical improvement. Further studies are needed to provide more evidence regarding this type of patients undergoing LVAD implantation.
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spelling pubmed-100984822023-04-14 Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis Khamees, Khalid Al Grasso, Elena Ibrahim, Ahmed Abdallah, Hassane Adbelhamed, Mohamad I. Sayin, Omer Lorusso, Roberto J Card Surg Regular Issue Papers BACKGROUND: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle‐cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outcomes of LVAD implantation in patients with sickle‐cell hemoglobinopathy at our institution. METHODS: This retrospective, observational, single‐center study was conducted on patients with sickle‐cell trait (SCT), who underwent LVAD implantation using the HeartMate3 LVAD. RESULTS: LVAD devices were implanted in four patients with SCT. All procedures were performed successfully. All patients had uneventful post‐implant course. Overall, the mean follow‐up time was 25 months (range 21–28 months) and showed an unremarkable post‐implant course. There was a significant improvement in hematological markers over the follow‐up period. CONCLUSIONS: Despite the limited numbers of patients enrolled in this study, our findings indicate that LVAD surgery is safe in SCD patients and offers remarkable clinical improvement. Further studies are needed to provide more evidence regarding this type of patients undergoing LVAD implantation. John Wiley and Sons Inc. 2022-11-22 2022-12 /pmc/articles/PMC10098482/ /pubmed/36413694 http://dx.doi.org/10.1111/jocs.17145 Text en © 2022 The Authors. Journal of Cardiac Surgery published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Issue Papers
Khamees, Khalid Al
Grasso, Elena
Ibrahim, Ahmed
Abdallah, Hassane
Adbelhamed, Mohamad I.
Sayin, Omer
Lorusso, Roberto
Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title_full Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title_fullStr Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title_full_unstemmed Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title_short Single‐center experience of LVAD implantation in patients with sickle‐cell trait: A retrospective analysis
title_sort single‐center experience of lvad implantation in patients with sickle‐cell trait: a retrospective analysis
topic Regular Issue Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098482/
https://www.ncbi.nlm.nih.gov/pubmed/36413694
http://dx.doi.org/10.1111/jocs.17145
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