Cargando…

Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes

α‐Amino acid derivatives are key components of the molecules of life. The synthesis of α‐amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we report a practical method for the preparation of α‐amino acid derivatives via direct hydrative amination of activate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Minghao, Tinelli, Roberto, Meyrelles, Ricardo, González, Leticia, Maryasin, Boris, Maulide, Nuno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098499/ https://www.ncbi.nlm.nih.gov/pubmed/36222199 http://dx.doi.org/10.1002/anie.202212399

Ejemplares similares

HFIP Mediates a Direct C−C Coupling between Michael Acceptors and Eschenmoser's salt
por: Lemmerer, Miran, et al.
Publicado: (2022)

Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes
por: Grant, Phillip S., et al.
Publicado: (2023)

Hydrative Aminoxylation of Ynamides: One Reaction, Two Mechanisms
por: Pinto, Alexandre, et al.
Publicado: (2018)

Direct Stereodivergent Olefination of Carbonyl Compounds with Sulfur Ylides
por: Merad, Jérémy, et al.
Publicado: (2022)

Redox‐Neutral Selenium‐Catalysed Isomerisation of para‐Hydroxamic Acids into para‐Aminophenols
por: Chuang, Hsiang‐Yu, et al.
Publicado: (2021)

Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
por: Tona, Veronica, et al.
Publicado: (2017)

A redox-neutral synthesis of ketones by coupling of alkenes and amides
por: Li, Jing, et al.
Publicado: (2019)

Machine Learning for Organic Synthesis: Are Robots Replacing Chemists?
por: Maryasin, Boris, et al.
Publicado: (2018)

Mechanistic Pathways in Amide Activation: Flexible Synthesis of Oxazoles and Imidazoles
por: Di Mauro, Giovanni, et al.
Publicado: (2017)

α‐Functionalisation of Ketones Through Metal‐Free Electrophilic Activation
por: Zawodny, Wojciech, et al.
Publicado: (2020)

Deployment of Sulfinimines in Charge-Accelerated Sulfonium Rearrangement Enables a Surrogate Asymmetric Mannich Reaction
por: Feng, Minghao, et al.
Publicado: (2022)

On the Stability of Disubstituted Cyclobutenes – A Computational Study
por: Maryasin, Boris, et al.
Publicado: (2018)

Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles
por: Gonçalves, Carlos R., et al.
Publicado: (2019)

Stereoselective Synthesis of Tertiary Allylic Amines by Titanium‐Catalyzed Hydroaminoalkylation of Alkynes with Tertiary Amines
por: Kaper, Tobias, et al.
Publicado: (2022)

Iodine-mediated hydration of alkynes on keto-functionalized scaffolds: mechanistic insight and the regiospecific hydration of internal alkynes
por: Lee, Zachary, et al.
Publicado: (2019)

Ni-catalyzed hydroaminoalkylation of alkynes with amines
por: Yao, Wei-Wei, et al.
Publicado: (2021)

Synthesis and structures of gold and copper carbene intermediates in catalytic amination of alkynes
por: Wang, Jiwei, et al.
Publicado: (2017)

Chemo- and Stereoselective Transition-Metal-Free Amination of Amides with Azides
por: Tona, Veronica, et al.
Publicado: (2016)

A General Acid‐Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes
por: Kaiser, Daniel, et al.
Publicado: (2019)

Tandem aldehyde–alkyne–amine coupling/cycloisomerization: A new synthesis of coumarins
por: Reddy, Maddi Sridhar, et al.
Publicado: (2013)

A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants
por: Chen, Yong, et al.
Publicado: (2019)

Leveraging Electron‐Deficient Iminium Intermediates in a General Synthesis of Valuable Amines
por: Hsu, Che‐Sheng, et al.
Publicado: (2022)

Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of α-Arylidene-butyrolactones
por: Lima, Samia R., et al.
Publicado: (2020)

Asymmetric hydroalkylation of alkynes and allenes with imidazolidinone derivatives: α-alkenylation of α-amino acids
por: Panahi, Farhad, et al.
Publicado: (2021)

Unusual mechanisms in Claisen rearrangements: an ionic fragmentation leading to a meta-selective rearrangement
por: Maryasin, Boris, et al.
Publicado: (2018)

Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters
por: Benedetti, Fabio, et al.
Publicado: (2016)

Direct Synthesis of Enamides via Electrophilic Activation of Amides
por: Spieß, Philipp, et al.
Publicado: (2021)

New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides
por: Honcharenko, Dmytro, et al.
Publicado: (2020)

Catalyst-dependent selectivity in sulfonium ylide cycloisomerization reactions
por: Oost, Rik, et al.
Publicado: (2018)

Polyphenylene-Based Solid Acid as an Efficient Catalyst for Activation and Hydration of Alkynes
por: Liu, Yiyun, et al.
Publicado: (2020)

Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
por: Rueping, Magnus, et al.
Publicado: (2011)

Galactopyranoside-Substituted N-Heterocyclic Carbene Gold(I) Complexes: Synthesis, Stability, and Catalytic Applications to Alkyne Hydration
por: Hobsteter, Ariana W., et al.
Publicado: (2022)

Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
por: Le, Yi, et al.
Publicado: (2019)

α‐Amidoaldehydes as Substrates in Rhodium‐Catalyzed Intermolecular Alkyne Hydroacylation: The Synthesis of α‐Amidoketones
por: Pal, Ritashree, et al.
Publicado: (2020)

Palladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes
por: Jiang, Tuo, et al.
Publicado: (2016)

Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines
por: Noble, Adam, et al.
Publicado: (2014)

Direct halosulfonylation of alkynes: an overview
por: Zhang, Yujun, et al.
Publicado: (2021)

Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis
por: Mayer, Robert J., et al.
Publicado: (2022)

Stereoretentive and regioselective selenium-catalyzed intermolecular propargylic C–H amination of alkynes
por: Maloney, T. Parker, et al.
Publicado: (2022)

Titanium-mediated reductive cross-coupling reactions of imines with terminal alkynes: An efficient route for the synthesis of stereodefined allylic amines
por: Mao, Kebin, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_g1a44d85lb2cba9ri993dp8njv