Ethnic‐specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population

Pathogenic variation in BRCA1 and BRCA2 (BRCA) causes high risk of breast and ovarian cancer, and BRCA variation data are important markers for BRCA‐related clinical cancer applications. However, comprehensive BRCA variation data are lacking from the Asian population despite its large population siz...

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Detalles Bibliográficos
Autores principales: Qin, Zixin, Li, Jiaheng, Tam, Benjamin, Sinha, Siddharth, Zhao, Bojin, Bhaskaran, Shanmuga Priya, Huang, Teng, Wu, Xiaobing, Chian, Jia Sheng, Guo, Maoni, Kou, Si Hoi, Lei, Huijun, Zhang, Li, Wang, Xiaoyu, Lagniton, Philip Naderev P., Xiao, Fengxia, Jiang, Xinyang, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Cancer Genetics and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098510/
https://www.ncbi.nlm.nih.gov/pubmed/36385461
http://dx.doi.org/10.1002/ijc.34359

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