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Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator

Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a met...

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Autores principales: Manna, Francesco, Pugliese, Mariagabriella, Buonanno, Francesca, Gherardi, Federica, Iannacone, Eva, La Verde, Giuseppe, Muto, Paolo, Arrichiello, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098582/
https://www.ncbi.nlm.nih.gov/pubmed/37050652
http://dx.doi.org/10.3390/s23073592
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author Manna, Francesco
Pugliese, Mariagabriella
Buonanno, Francesca
Gherardi, Federica
Iannacone, Eva
La Verde, Giuseppe
Muto, Paolo
Arrichiello, Cecilia
author_facet Manna, Francesco
Pugliese, Mariagabriella
Buonanno, Francesca
Gherardi, Federica
Iannacone, Eva
La Verde, Giuseppe
Muto, Paolo
Arrichiello, Cecilia
author_sort Manna, Francesco
collection PubMed
description Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a method for treatment plan verification for skin surface BT is reported. Chips of thermoluminescent dosimeters (TLDs) were used for dose point measurements. High-dose-rate treatments were simulated and delivered through a custom-flap applicator provided with four fixed catheters to guide the Iridium-192 (Ir-192) source by way of a remote afterloading system. A flat water-equivalent phantom was used to simulate patient skin. Elekta TPS Oncentra Brachy was used for planning. TLDs were calibrated to Ir-192 through an indirect method of linear interpolation between calibration factors (CFs) measured for 250 kV X-rays, Cesium-137, and Cobalt-60. Subsequently, plans were designed and delivered to test the reproducibility of the irradiation set-up and to make comparisons between planned and delivered dose. The obtained CF for Ir-192 was (4.96 ± 0.25) μC/Gy. Deviations between measured and TPS calculated doses for multi-catheter treatment configuration ranged from −8.4% to 13.3% with an average of 0.6%. TLDs could be included in clinical practice for QA in skin BT with a customized flap applicator.
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spelling pubmed-100985822023-04-14 Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator Manna, Francesco Pugliese, Mariagabriella Buonanno, Francesca Gherardi, Federica Iannacone, Eva La Verde, Giuseppe Muto, Paolo Arrichiello, Cecilia Sensors (Basel) Article Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a method for treatment plan verification for skin surface BT is reported. Chips of thermoluminescent dosimeters (TLDs) were used for dose point measurements. High-dose-rate treatments were simulated and delivered through a custom-flap applicator provided with four fixed catheters to guide the Iridium-192 (Ir-192) source by way of a remote afterloading system. A flat water-equivalent phantom was used to simulate patient skin. Elekta TPS Oncentra Brachy was used for planning. TLDs were calibrated to Ir-192 through an indirect method of linear interpolation between calibration factors (CFs) measured for 250 kV X-rays, Cesium-137, and Cobalt-60. Subsequently, plans were designed and delivered to test the reproducibility of the irradiation set-up and to make comparisons between planned and delivered dose. The obtained CF for Ir-192 was (4.96 ± 0.25) μC/Gy. Deviations between measured and TPS calculated doses for multi-catheter treatment configuration ranged from −8.4% to 13.3% with an average of 0.6%. TLDs could be included in clinical practice for QA in skin BT with a customized flap applicator. MDPI 2023-03-30 /pmc/articles/PMC10098582/ /pubmed/37050652 http://dx.doi.org/10.3390/s23073592 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manna, Francesco
Pugliese, Mariagabriella
Buonanno, Francesca
Gherardi, Federica
Iannacone, Eva
La Verde, Giuseppe
Muto, Paolo
Arrichiello, Cecilia
Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title_full Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title_fullStr Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title_full_unstemmed Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title_short Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
title_sort use of thermoluminescence dosimetry for qa in high-dose-rate skin surface brachytherapy with custom-flap applicator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098582/
https://www.ncbi.nlm.nih.gov/pubmed/37050652
http://dx.doi.org/10.3390/s23073592
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