Cargando…
Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator
Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a met...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098582/ https://www.ncbi.nlm.nih.gov/pubmed/37050652 http://dx.doi.org/10.3390/s23073592 |
_version_ | 1785024844679610368 |
---|---|
author | Manna, Francesco Pugliese, Mariagabriella Buonanno, Francesca Gherardi, Federica Iannacone, Eva La Verde, Giuseppe Muto, Paolo Arrichiello, Cecilia |
author_facet | Manna, Francesco Pugliese, Mariagabriella Buonanno, Francesca Gherardi, Federica Iannacone, Eva La Verde, Giuseppe Muto, Paolo Arrichiello, Cecilia |
author_sort | Manna, Francesco |
collection | PubMed |
description | Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a method for treatment plan verification for skin surface BT is reported. Chips of thermoluminescent dosimeters (TLDs) were used for dose point measurements. High-dose-rate treatments were simulated and delivered through a custom-flap applicator provided with four fixed catheters to guide the Iridium-192 (Ir-192) source by way of a remote afterloading system. A flat water-equivalent phantom was used to simulate patient skin. Elekta TPS Oncentra Brachy was used for planning. TLDs were calibrated to Ir-192 through an indirect method of linear interpolation between calibration factors (CFs) measured for 250 kV X-rays, Cesium-137, and Cobalt-60. Subsequently, plans were designed and delivered to test the reproducibility of the irradiation set-up and to make comparisons between planned and delivered dose. The obtained CF for Ir-192 was (4.96 ± 0.25) μC/Gy. Deviations between measured and TPS calculated doses for multi-catheter treatment configuration ranged from −8.4% to 13.3% with an average of 0.6%. TLDs could be included in clinical practice for QA in skin BT with a customized flap applicator. |
format | Online Article Text |
id | pubmed-10098582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100985822023-04-14 Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator Manna, Francesco Pugliese, Mariagabriella Buonanno, Francesca Gherardi, Federica Iannacone, Eva La Verde, Giuseppe Muto, Paolo Arrichiello, Cecilia Sensors (Basel) Article Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a method for treatment plan verification for skin surface BT is reported. Chips of thermoluminescent dosimeters (TLDs) were used for dose point measurements. High-dose-rate treatments were simulated and delivered through a custom-flap applicator provided with four fixed catheters to guide the Iridium-192 (Ir-192) source by way of a remote afterloading system. A flat water-equivalent phantom was used to simulate patient skin. Elekta TPS Oncentra Brachy was used for planning. TLDs were calibrated to Ir-192 through an indirect method of linear interpolation between calibration factors (CFs) measured for 250 kV X-rays, Cesium-137, and Cobalt-60. Subsequently, plans were designed and delivered to test the reproducibility of the irradiation set-up and to make comparisons between planned and delivered dose. The obtained CF for Ir-192 was (4.96 ± 0.25) μC/Gy. Deviations between measured and TPS calculated doses for multi-catheter treatment configuration ranged from −8.4% to 13.3% with an average of 0.6%. TLDs could be included in clinical practice for QA in skin BT with a customized flap applicator. MDPI 2023-03-30 /pmc/articles/PMC10098582/ /pubmed/37050652 http://dx.doi.org/10.3390/s23073592 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Manna, Francesco Pugliese, Mariagabriella Buonanno, Francesca Gherardi, Federica Iannacone, Eva La Verde, Giuseppe Muto, Paolo Arrichiello, Cecilia Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title | Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title_full | Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title_fullStr | Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title_full_unstemmed | Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title_short | Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator |
title_sort | use of thermoluminescence dosimetry for qa in high-dose-rate skin surface brachytherapy with custom-flap applicator |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098582/ https://www.ncbi.nlm.nih.gov/pubmed/37050652 http://dx.doi.org/10.3390/s23073592 |
work_keys_str_mv | AT mannafrancesco useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT pugliesemariagabriella useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT buonannofrancesca useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT gherardifederica useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT iannaconeeva useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT laverdegiuseppe useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT mutopaolo useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator AT arrichiellocecilia useofthermoluminescencedosimetryforqainhighdoserateskinsurfacebrachytherapywithcustomflapapplicator |