Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols

Herein, we report an electrochemical oxidative palladium‐catalyzed carbonylation‐carbocyclization of enallenols to afford γ‐lactones and spirolactones, which proceeds with excellent chemoselectivity. Interestingly, electrocatalysis was found to have an accelerating effect on the rate of the tandem p...

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Autores principales: Zhang, Jianwei, Das, Biswanath, Verho, Oscar, Bäckvall, Jan‐E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098644/
https://www.ncbi.nlm.nih.gov/pubmed/36222322
http://dx.doi.org/10.1002/anie.202212131
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author Zhang, Jianwei
Das, Biswanath
Verho, Oscar
Bäckvall, Jan‐E.
author_facet Zhang, Jianwei
Das, Biswanath
Verho, Oscar
Bäckvall, Jan‐E.
author_sort Zhang, Jianwei
collection PubMed
description Herein, we report an electrochemical oxidative palladium‐catalyzed carbonylation‐carbocyclization of enallenols to afford γ‐lactones and spirolactones, which proceeds with excellent chemoselectivity. Interestingly, electrocatalysis was found to have an accelerating effect on the rate of the tandem process, leading to a more efficient reaction than that under chemical redox conditions.
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spelling pubmed-100986442023-04-14 Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols Zhang, Jianwei Das, Biswanath Verho, Oscar Bäckvall, Jan‐E. Angew Chem Int Ed Engl Communications Herein, we report an electrochemical oxidative palladium‐catalyzed carbonylation‐carbocyclization of enallenols to afford γ‐lactones and spirolactones, which proceeds with excellent chemoselectivity. Interestingly, electrocatalysis was found to have an accelerating effect on the rate of the tandem process, leading to a more efficient reaction than that under chemical redox conditions. John Wiley and Sons Inc. 2022-11-04 2022-12-05 /pmc/articles/PMC10098644/ /pubmed/36222322 http://dx.doi.org/10.1002/anie.202212131 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Zhang, Jianwei
Das, Biswanath
Verho, Oscar
Bäckvall, Jan‐E.
Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title_full Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title_fullStr Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title_full_unstemmed Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title_short Electrochemical Palladium‐Catalyzed Oxidative Carbonylation‐Cyclization of Enallenols
title_sort electrochemical palladium‐catalyzed oxidative carbonylation‐cyclization of enallenols
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098644/
https://www.ncbi.nlm.nih.gov/pubmed/36222322
http://dx.doi.org/10.1002/anie.202212131
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AT dasbiswanath electrochemicalpalladiumcatalyzedoxidativecarbonylationcyclizationofenallenols
AT verhooscar electrochemicalpalladiumcatalyzedoxidativecarbonylationcyclizationofenallenols
AT backvalljane electrochemicalpalladiumcatalyzedoxidativecarbonylationcyclizationofenallenols

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