Design of a Protein with Improved Thermal Stability by an Evolution‐Based Generative Model

Efficient design of functional proteins with higher thermal stability remains challenging especially for highly diverse sequence variants. Considering the evolutionary pressure on protein folds, sequence design optimizing evolutionary fitness could help designing folds with higher stability. Using a...

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Detalles Bibliográficos
Autores principales: Tian, Pengfei, Lemaire, Adrien, Sénéchal, Fabien, Habrylo, Olivier, Antonietti, Viviane, Sonnet, Pascal, Lefebvre, Valérie, Isa Marin, Frederikke, Best, Robert B., Pelloux, Jérôme, Mercadante, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098751/
https://www.ncbi.nlm.nih.gov/pubmed/36259321
http://dx.doi.org/10.1002/anie.202202711

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