Hydrogen‐Bond‐Modulated Nucleofugality of Se(III) Species to Enable Photoredox‐Catalytic Semipinacol Manifolds

Chemical bond activations mediated by H‐bond interactions involving highly electronegative elements such as nitrogen and oxygen are powerful tactics in modern catalysis research. On the contrary, kindred catalytic regimes in which heavier, less electronegative elements such as selenium engage in H‐bond interactions to co‐activate C−Se σ‐bonds under oxidative conditions are elusive. Traditional strategies to enhance the nucleofugality of selenium residues predicate on the oxidative addition of electrophiles onto Se(II)‐centers, which entails the elimination of the resulting Se(IV) moieties. Catalytic procedures in which Se(IV) nucleofuges are substituted rather than eliminated are very rare and, so far, not applicable to carbon‐carbon bond formations. In this study, we introduce an unprecedented combination of O−H⋅⋅⋅Se H‐bond interactions and single electron oxidation to catalytically generate Se(III) nucleofuges that allow for the formation of new C−C σ‐bonds by means of a type I semipinacol process in high yields and excellent selectivity.