Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole

Accurate prediction of CYP2D6 phenotype from genotype information is important to support safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate CYP2D6 genotype–phenotype translation, there remains a need to investigate the enzyme activity associated with individual CYP2...

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Detalles Bibliográficos
Autores principales: Frederiksen, Trine, Areberg, Johan, Raoufinia, Arash, Schmidt, Ellen, Stage, Tore Bjerregaard, Brøsen, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099095/
https://www.ncbi.nlm.nih.gov/pubmed/36350097
http://dx.doi.org/10.1002/cpt.2791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099095/
https://www.ncbi.nlm.nih.gov/pubmed/36350097
http://dx.doi.org/10.1002/cpt.2791

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