The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

T cell responses play an important role in protection against beta-coronavirus infections, including SARS-CoV-2, where they associate with decreased COVID-19 disease severity and duration. To enhance T cell immunity across epitopes infrequently altered in SARS-CoV-2 variants, we designed BNT162b4, a...

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Detalles Bibliográficos
Autores principales: Arieta, Christina M., Xie, Yushu Joy, Rothenberg, Daniel A., Diao, Huitian, Harjanto, Dewi, Meda, Shirisha, Marquart, Krisann, Koenitzer, Byron, Sciuto, Tracey E., Lobo, Alexander, Zuiani, Adam, Krumm, Stefanie A., Cadima Couto, Carla Iris, Hein, Stephanie, Heinen, André P., Ziegenhals, Thomas, Liu-Lupo, Yunpeng, Vogel, Annette B., Srouji, John R., Fesser, Stephanie, Thanki, Kaushik, Walzer, Kerstin, Addona, Theresa A., Türeci, Özlem, Şahin, Uğur, Gaynor, Richard B., Poran, Asaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099181/
https://www.ncbi.nlm.nih.gov/pubmed/37164012
http://dx.doi.org/10.1016/j.cell.2023.04.007

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