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Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD

Disruption of the nuclear pore complex (NPC) and nucleocytoplasmic transport (NCT) have been implicated in the pathogenesis of neurodegenerative diseases. A GGGGCC hexanucleotide repeat expansion (HRE) in an intron of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis...

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Detalles Bibliográficos
Autores principales:	Dubey, Sandeep Kumar, Maulding, Kirstin, Sung, Hyun, Lloyd, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099287/ https://www.ncbi.nlm.nih.gov/pubmed/36130523 http://dx.doi.org/10.1016/j.celrep.2022.111379

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