Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability

BACKGROUND AND OBJECTIVES: Autoantibodies to leucine-rich glioma inactivated protein 1 (LGI1) cause an autoimmune limbic encephalitis with frequent focal seizures and anterograde memory dysfunction. LGI1 is a neuronal secreted linker protein with 2 functional domains: the leucine-rich repeat (LRR) a...

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Detalles Bibliográficos
Autores principales: Sell, Josefine, Rahmati, Vahid, Kempfer, Marin, Irani, Sarosh R., Ritzau-Jost, Andreas, Hallermann, Stefan, Geis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099296/
https://www.ncbi.nlm.nih.gov/pubmed/37028941
http://dx.doi.org/10.1212/NXI.0000000000200096

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