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Dissolvable Topical Formulations for Burst and Constant Delivery of Vitamin C
[Image: see text] Healthy skin has a high vitamin C concentration that protects against ultraviolet (UV)-induced damage, promotes wound healing, and lowers cancer risk. The present contribution describes two drug delivery systems for topical administration of vitamin C. The electrospun poly(vinyl al...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099438/ https://www.ncbi.nlm.nih.gov/pubmed/37065060 http://dx.doi.org/10.1021/acsomega.2c06738 |
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author | Calzado-Delgado, Mar Guerrero-Pérez, M. Olga Yeung, King Lun |
author_facet | Calzado-Delgado, Mar Guerrero-Pérez, M. Olga Yeung, King Lun |
author_sort | Calzado-Delgado, Mar |
collection | PubMed |
description | [Image: see text] Healthy skin has a high vitamin C concentration that protects against ultraviolet (UV)-induced damage, promotes wound healing, and lowers cancer risk. The present contribution describes two drug delivery systems for topical administration of vitamin C. The electrospun poly(vinyl alcohol) (PVA) nanofiber carrier of vitamin C exhibits a burst release profile (66 mg/g/h followed by 6.3 mg/g/h). In comparison, a new composite PVA nanofiber–molecular capsule delivers vitamin C at a constant rate (8.2 mg/g/h) with a zeroth-order release profile for better therapeutic management. Both delivery systems protect vitamin C and afford increased heat stability. The molecular capsules of β-cyclodextrin with the vitamin C inclusion complex are immobilized on cellulose acetate and electrosprayed onto an electrospun PVA nanofiber mat. |
format | Online Article Text |
id | pubmed-10099438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100994382023-04-14 Dissolvable Topical Formulations for Burst and Constant Delivery of Vitamin C Calzado-Delgado, Mar Guerrero-Pérez, M. Olga Yeung, King Lun ACS Omega [Image: see text] Healthy skin has a high vitamin C concentration that protects against ultraviolet (UV)-induced damage, promotes wound healing, and lowers cancer risk. The present contribution describes two drug delivery systems for topical administration of vitamin C. The electrospun poly(vinyl alcohol) (PVA) nanofiber carrier of vitamin C exhibits a burst release profile (66 mg/g/h followed by 6.3 mg/g/h). In comparison, a new composite PVA nanofiber–molecular capsule delivers vitamin C at a constant rate (8.2 mg/g/h) with a zeroth-order release profile for better therapeutic management. Both delivery systems protect vitamin C and afford increased heat stability. The molecular capsules of β-cyclodextrin with the vitamin C inclusion complex are immobilized on cellulose acetate and electrosprayed onto an electrospun PVA nanofiber mat. American Chemical Society 2023-03-27 /pmc/articles/PMC10099438/ /pubmed/37065060 http://dx.doi.org/10.1021/acsomega.2c06738 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Calzado-Delgado, Mar Guerrero-Pérez, M. Olga Yeung, King Lun Dissolvable Topical Formulations for Burst and Constant Delivery of Vitamin C |
title | Dissolvable Topical
Formulations for Burst and Constant
Delivery of Vitamin C |
title_full | Dissolvable Topical
Formulations for Burst and Constant
Delivery of Vitamin C |
title_fullStr | Dissolvable Topical
Formulations for Burst and Constant
Delivery of Vitamin C |
title_full_unstemmed | Dissolvable Topical
Formulations for Burst and Constant
Delivery of Vitamin C |
title_short | Dissolvable Topical
Formulations for Burst and Constant
Delivery of Vitamin C |
title_sort | dissolvable topical
formulations for burst and constant
delivery of vitamin c |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099438/ https://www.ncbi.nlm.nih.gov/pubmed/37065060 http://dx.doi.org/10.1021/acsomega.2c06738 |
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