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New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers

The clinical treatment of DNA-repair defective tumours has been revolutionised by the use of poly(ADP) ribose polymerase (PARP) inhibitors. However, the efficacy of these compounds is hampered by resistance, which is attributed to numerous mechanisms including rewiring of the DNA damage response to...

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Detalles Bibliográficos
Autores principales:	Bayley, Rachel, Sweatman, Ellie, Higgs, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OAE Publishing Inc. 2023
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099596/ https://www.ncbi.nlm.nih.gov/pubmed/37065862 http://dx.doi.org/10.20517/cdr.2022.73

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