Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)‐γ‐N‐methyl‐β‐hydroxy‐histidine moiety. Corramycin exhibits anti‐Gram‐negative activity against Escherichia coli (E. coli) and is ta...

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Detalles Bibliográficos
Autores principales: Couturier, Cédric, Groß, Sebastian, von Tesmar, Alexander, Hoffmann, Judith, Deckarm, Selina, Fievet, Anouchka, Dubarry, Nelly, Taillier, Thomas, Pöverlein, Christoph, Stump, Heike, Kurz, Michael, Toti, Luigi, Haag Richter, Sabine, Schummer, Dietmar, Sizun, Philippe, Hoffmann, Michael, Prasad Awal, Ram, Zaburannyi, Nestor, Harmrolfs, Kirsten, Wink, Joachim, Lessoud, Emilie, Vermat, Thierry, Cazals, Veronique, Silve, Sandra, Bauer, Armin, Mourez, Michael, Fraisse, Laurent, Leroi‐Geissler, Corinne, Rey, Astrid, Versluys, Stéphanie, Bacqué, Eric, Müller, Rolf, Renard, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099666/
https://www.ncbi.nlm.nih.gov/pubmed/36197755
http://dx.doi.org/10.1002/anie.202210747

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