Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS

Mutations in the human Superoxide dismutase 1 (hSOD1) gene are well‐established cause of the motor neuron disease ALS. Patients and transgenic (Tg) ALS model mice carrying mutant variants develop hSOD1 aggregates in the CNS. We have identified two hSOD1 aggregate strains, which both transmit spreadi...

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Detalles Bibliográficos
Autores principales: Nordström, Ulrika, Lang, Lisa, Ekhtiari Bidhendi, Elaheh, Zetterström, Per, Oliveberg, Mikael, Danielsson, Jens, Andersen, Peter M., Marklund, Stefan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099669/
https://www.ncbi.nlm.nih.gov/pubmed/36326589
http://dx.doi.org/10.1111/jnc.15718

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