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A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma
SIMPLE SUMMARY: A retrospective study was performed on 955 eligible patients with stage I lung adenocarcinoma (LUAD) after surgery. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and ur...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099732/ https://www.ncbi.nlm.nih.gov/pubmed/36980604 http://dx.doi.org/10.3390/cancers15061718 |
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author | Qian, Jia-Yi Hao, Yun Yu, Hai-Hong Wu, Lei-Lei Liu, Zhi-Yuan Peng, Qiao Li, Zhi-Xin Li, Kun Liu, Yu’e Wang, Rang-Rang Xie, Dong |
author_facet | Qian, Jia-Yi Hao, Yun Yu, Hai-Hong Wu, Lei-Lei Liu, Zhi-Yuan Peng, Qiao Li, Zhi-Xin Li, Kun Liu, Yu’e Wang, Rang-Rang Xie, Dong |
author_sort | Qian, Jia-Yi |
collection | PubMed |
description | SIMPLE SUMMARY: A retrospective study was performed on 955 eligible patients with stage I lung adenocarcinoma (LUAD) after surgery. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and uric acid (UA). SOS is an independent prognostic indicator for stage I LUAD. In addition, the constructed nomogram based on SOS could accurately predict the survival of those patients. ABSTRACT: This study aimed to construct an effective nomogram based on the clinical and oxidative stress-related characteristics to predict the prognosis of stage I lung adenocarcinoma (LUAD). A retrospective study was performed on 955 eligible patients with stage I LUAD after surgery at our hospital. The relationship between systematic-oxidative-stress biomarkers and the prognosis was analyzed. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and uric acid (UA). SOS was an independent prognostic factor for stage I LUADs, and the nomogram based on SOS and clinical characteristics could accurately predict the prognosis of these patients. The nomogram had a high concordance index (C-index) (0.684, 95% CI, 0.656–0.712), and the calibration curves for recurrence-free survival (RFS) probabilities showed a strong agreement between the nomogram prediction and actual observation. Additionally, the patients were divided into two groups according to the cut-off value of risk points based on the nomogram, and a significant difference in RFS was observed between the high-risk and low-risk groups (p < 0.0001). SOS is an independent prognostic indicator for stage I LUAD. These things considered, the constructed nomogram based on SOS could accurately predict the survival of those patients. |
format | Online Article Text |
id | pubmed-10099732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100997322023-04-14 A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma Qian, Jia-Yi Hao, Yun Yu, Hai-Hong Wu, Lei-Lei Liu, Zhi-Yuan Peng, Qiao Li, Zhi-Xin Li, Kun Liu, Yu’e Wang, Rang-Rang Xie, Dong Cancers (Basel) Article SIMPLE SUMMARY: A retrospective study was performed on 955 eligible patients with stage I lung adenocarcinoma (LUAD) after surgery. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and uric acid (UA). SOS is an independent prognostic indicator for stage I LUAD. In addition, the constructed nomogram based on SOS could accurately predict the survival of those patients. ABSTRACT: This study aimed to construct an effective nomogram based on the clinical and oxidative stress-related characteristics to predict the prognosis of stage I lung adenocarcinoma (LUAD). A retrospective study was performed on 955 eligible patients with stage I LUAD after surgery at our hospital. The relationship between systematic-oxidative-stress biomarkers and the prognosis was analyzed. The systematic oxidative stress score (SOS) was established based on three biochemical indicators, including serum creatinine (CRE), lactate dehydrogenase (LDH), and uric acid (UA). SOS was an independent prognostic factor for stage I LUADs, and the nomogram based on SOS and clinical characteristics could accurately predict the prognosis of these patients. The nomogram had a high concordance index (C-index) (0.684, 95% CI, 0.656–0.712), and the calibration curves for recurrence-free survival (RFS) probabilities showed a strong agreement between the nomogram prediction and actual observation. Additionally, the patients were divided into two groups according to the cut-off value of risk points based on the nomogram, and a significant difference in RFS was observed between the high-risk and low-risk groups (p < 0.0001). SOS is an independent prognostic indicator for stage I LUAD. These things considered, the constructed nomogram based on SOS could accurately predict the survival of those patients. MDPI 2023-03-11 /pmc/articles/PMC10099732/ /pubmed/36980604 http://dx.doi.org/10.3390/cancers15061718 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Qian, Jia-Yi Hao, Yun Yu, Hai-Hong Wu, Lei-Lei Liu, Zhi-Yuan Peng, Qiao Li, Zhi-Xin Li, Kun Liu, Yu’e Wang, Rang-Rang Xie, Dong A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title | A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title_full | A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title_fullStr | A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title_full_unstemmed | A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title_short | A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma |
title_sort | novel systematic oxidative stress score predicts the survival of patients with early-stage lung adenocarcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099732/ https://www.ncbi.nlm.nih.gov/pubmed/36980604 http://dx.doi.org/10.3390/cancers15061718 |
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