Cargando…
Stafiba: A STAT5‐Selective Small‐Molecule Inhibitor
The transcription factors STAT5a and STAT5b are constitutively active in many human tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising applications in tumor biology. We recently reported resorcinol bisphosphate as a moderately active inhibitor of the protein‐pro...
Autores principales: | Eckhardt, Katrin S., Münzel, Theresa, Gräb, Julian, Berg, Thorsten |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099813/ https://www.ncbi.nlm.nih.gov/pubmed/36300584 http://dx.doi.org/10.1002/cbic.202200553 |
Ejemplares similares
-
The Selectivity of Fosfosal for STAT5b over STAT5a is Mediated by Arg566 in the Linker Domain
por: Gräb, Julian, et al.
Publicado: (2020) -
Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a**
por: Elumalai, Nagarajan, et al.
Publicado: (2015) -
Nanomolar-Potency Small Molecule Inhibitor of STAT5
Protein
por: Cumaraswamy, Abbarna A., et al.
Publicado: (2014) -
Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b
por: Elumalai, Nagarajan, et al.
Publicado: (2017) -
Small Molecule Inhibitors of Interferon‐Induced JAK‐STAT Signalling
por: Thoidingjam, Leishemba K., et al.
Publicado: (2022)