Increased prevalence of the founder BRCA1 c.5309G>T and recurrent BRCA2 c.1310_1313delAAGA mutations in breast cancer families from Northerstern region of Morocco: evidence of geographical specificity and high relevance for genetic counseling

BACKGROUND: Inherited mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 (BRCA1/2) confer high risks of breast and ovarian cancer. Because the contribution of BRCA1/2 germline mutations to BC in the Northeastern population of Morocco remains largely unknown, we conducted this first...

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Detalles Bibliográficos
Autores principales: Melki, Rahma, Melloul, Marouane, Aissaoui, Souria, EL Harroudi, Tijani, Boukhatem, Noureddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099884/
https://www.ncbi.nlm.nih.gov/pubmed/37055759
http://dx.doi.org/10.1186/s12885-023-10822-5

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