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Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women

OBJECTIVE: To explore the contribution of pregnancy‐related complications on the prevalence of extremely, very and late preterm births in singleton and twin pregnancies. To study the risk of spontaneous preterm birth in twin pregnancies compared with singleton pregnancies. DESIGN: Population‐based r...

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Autores principales: Tingleff, Tiril, Räisänen, Sari, Vikanes, Åse, Sandvik, Leiv, Sugulle, Meryam, Murzakanova, Gulim, Laine, Katariina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099984/
https://www.ncbi.nlm.nih.gov/pubmed/36372962
http://dx.doi.org/10.1111/1471-0528.17344
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author Tingleff, Tiril
Räisänen, Sari
Vikanes, Åse
Sandvik, Leiv
Sugulle, Meryam
Murzakanova, Gulim
Laine, Katariina
author_facet Tingleff, Tiril
Räisänen, Sari
Vikanes, Åse
Sandvik, Leiv
Sugulle, Meryam
Murzakanova, Gulim
Laine, Katariina
author_sort Tingleff, Tiril
collection PubMed
description OBJECTIVE: To explore the contribution of pregnancy‐related complications on the prevalence of extremely, very and late preterm births in singleton and twin pregnancies. To study the risk of spontaneous preterm birth in twin pregnancies compared with singleton pregnancies. DESIGN: Population‐based registry study. SETTING: Medical birth registry of Norway and Statistics Norway. POPULATION: Nulliparous women with singleton (n = 472 449) or twin (n = 8727) births during 1999–2018. METHODS: Prevalence rates of pregnancy‐related complications for extremely, very and late preterm birth in twin and singleton pregnancies were calculated with 95% confidence intervals. Multivariable logistic regression was applied to assess odds ratios for preterm birth, adjusted for obstetric and socio‐economic factors. MAIN OUTCOME MEASURES: Extremely preterm (<28(+0) weeks of gestation), very preterm (28(+0)–33(+6) weeks of gestation) and late preterm (34(+0)–36(+6) weeks of geatation) birth. RESULTS: Preterm birth was significantly more prevalent in twin pregnancies than in singleton pregnancies in all categories: all preterm (54.7% vs 6.1%), extremely preterm (3.6% vs 0.4%), very preterm (18.2% vs 1.4%) and late preterm (33.0% vs 4.3%) births. Stillbirth, congenital malformation and pre‐eclampsia were more prevalent in twin pregnancies than in singleton pregnancies, but the prevalence of complications differed in the three categories of preterm birth. Pre‐eclampsia was more prevalent in singleton than in twin pregnancies ending in extremely and very preterm birth. The adjusted odds of spontaneous preterm live birth were between 19‐ and 54‐fold greater in twin pregnancies than in singleton pregnancies. CONCLUSIONS: Singleton and twin pregnancies seem to have different pathways leading to extremely, very and late preterm birth.
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spelling pubmed-100999842023-04-14 Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women Tingleff, Tiril Räisänen, Sari Vikanes, Åse Sandvik, Leiv Sugulle, Meryam Murzakanova, Gulim Laine, Katariina BJOG Research Articles OBJECTIVE: To explore the contribution of pregnancy‐related complications on the prevalence of extremely, very and late preterm births in singleton and twin pregnancies. To study the risk of spontaneous preterm birth in twin pregnancies compared with singleton pregnancies. DESIGN: Population‐based registry study. SETTING: Medical birth registry of Norway and Statistics Norway. POPULATION: Nulliparous women with singleton (n = 472 449) or twin (n = 8727) births during 1999–2018. METHODS: Prevalence rates of pregnancy‐related complications for extremely, very and late preterm birth in twin and singleton pregnancies were calculated with 95% confidence intervals. Multivariable logistic regression was applied to assess odds ratios for preterm birth, adjusted for obstetric and socio‐economic factors. MAIN OUTCOME MEASURES: Extremely preterm (<28(+0) weeks of gestation), very preterm (28(+0)–33(+6) weeks of gestation) and late preterm (34(+0)–36(+6) weeks of geatation) birth. RESULTS: Preterm birth was significantly more prevalent in twin pregnancies than in singleton pregnancies in all categories: all preterm (54.7% vs 6.1%), extremely preterm (3.6% vs 0.4%), very preterm (18.2% vs 1.4%) and late preterm (33.0% vs 4.3%) births. Stillbirth, congenital malformation and pre‐eclampsia were more prevalent in twin pregnancies than in singleton pregnancies, but the prevalence of complications differed in the three categories of preterm birth. Pre‐eclampsia was more prevalent in singleton than in twin pregnancies ending in extremely and very preterm birth. The adjusted odds of spontaneous preterm live birth were between 19‐ and 54‐fold greater in twin pregnancies than in singleton pregnancies. CONCLUSIONS: Singleton and twin pregnancies seem to have different pathways leading to extremely, very and late preterm birth. John Wiley and Sons Inc. 2022-11-21 2023-03 /pmc/articles/PMC10099984/ /pubmed/36372962 http://dx.doi.org/10.1111/1471-0528.17344 Text en © 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Tingleff, Tiril
Räisänen, Sari
Vikanes, Åse
Sandvik, Leiv
Sugulle, Meryam
Murzakanova, Gulim
Laine, Katariina
Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title_full Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title_fullStr Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title_full_unstemmed Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title_short Different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
title_sort different pathways for preterm birth between singleton and twin pregnancies: a population‐based registry study of 481 176 nulliparous women
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099984/
https://www.ncbi.nlm.nih.gov/pubmed/36372962
http://dx.doi.org/10.1111/1471-0528.17344
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