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Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review

BACKGROUND: Hyperglycaemia is common in patients with acute brain injury admitted to an intensive care unit (ICU). Many studies have found associations between development of hyperglycaemia and increased mortality in hospitalised patients. However, the optimal target for blood glucose control is unk...

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Autores principales: Fenger, Anne‐Sophie Worm, Olsen, Markus Harboe, Fabritius, Maria Louise, Riberholt, Christian Gunge, Møller, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099998/
https://www.ncbi.nlm.nih.gov/pubmed/36310523
http://dx.doi.org/10.1111/aas.14166
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author Fenger, Anne‐Sophie Worm
Olsen, Markus Harboe
Fabritius, Maria Louise
Riberholt, Christian Gunge
Møller, Kirsten
author_facet Fenger, Anne‐Sophie Worm
Olsen, Markus Harboe
Fabritius, Maria Louise
Riberholt, Christian Gunge
Møller, Kirsten
author_sort Fenger, Anne‐Sophie Worm
collection PubMed
description BACKGROUND: Hyperglycaemia is common in patients with acute brain injury admitted to an intensive care unit (ICU). Many studies have found associations between development of hyperglycaemia and increased mortality in hospitalised patients. However, the optimal target for blood glucose control is unknown. We want to conduct a systematic review with meta‐analysis and trial sequential analysis to explore the beneficial and harmful effects of restrictive versus liberal glucose control on patient outcomes in adults with severe acute brain injury. METHODS: We will systematically search medical databases including CENTRAL, Embase, MEDLINE and trial registries. We will search the following websites for ongoing or unpublished trials: http://www.controlled-trials.com/, http://www.clinicaltrials.gov/, www.eudraCT.com, http://centerwatch.com/, The Cochrane Library's CENTRAL, PubMed, EMBASE, Science Citation Index Expanded and CINAHL. Two authors will independently review and select trials and extract data. We will include randomised trials comparing levels of glucose control in our analyses and observational studies will be included to address potential harms. The primary outcomes are defined as all‐cause mortality, functional outcome and health‐related quality of life. Secondary outcomes include serious adverse events including hypoglycaemia, length of ICU stay and duration of mechanical ventilation, and explorative outcomes including intracranial pressure and infection. Trial Sequential Analysis will be used to investigate the risk of type I error due to repetitive testing and to further explore imprecision. Quality of trials will be evaluated using the Cochrane Risk of Bias tool, and quality of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. DISCUSSION: The results of the systematic review will be disseminated through peer‐reviewed publication. With the review, we hope to inform future randomised clinical trials and improve clinical practice.
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spelling pubmed-100999982023-04-14 Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review Fenger, Anne‐Sophie Worm Olsen, Markus Harboe Fabritius, Maria Louise Riberholt, Christian Gunge Møller, Kirsten Acta Anaesthesiol Scand Special Articles BACKGROUND: Hyperglycaemia is common in patients with acute brain injury admitted to an intensive care unit (ICU). Many studies have found associations between development of hyperglycaemia and increased mortality in hospitalised patients. However, the optimal target for blood glucose control is unknown. We want to conduct a systematic review with meta‐analysis and trial sequential analysis to explore the beneficial and harmful effects of restrictive versus liberal glucose control on patient outcomes in adults with severe acute brain injury. METHODS: We will systematically search medical databases including CENTRAL, Embase, MEDLINE and trial registries. We will search the following websites for ongoing or unpublished trials: http://www.controlled-trials.com/, http://www.clinicaltrials.gov/, www.eudraCT.com, http://centerwatch.com/, The Cochrane Library's CENTRAL, PubMed, EMBASE, Science Citation Index Expanded and CINAHL. Two authors will independently review and select trials and extract data. We will include randomised trials comparing levels of glucose control in our analyses and observational studies will be included to address potential harms. The primary outcomes are defined as all‐cause mortality, functional outcome and health‐related quality of life. Secondary outcomes include serious adverse events including hypoglycaemia, length of ICU stay and duration of mechanical ventilation, and explorative outcomes including intracranial pressure and infection. Trial Sequential Analysis will be used to investigate the risk of type I error due to repetitive testing and to further explore imprecision. Quality of trials will be evaluated using the Cochrane Risk of Bias tool, and quality of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. DISCUSSION: The results of the systematic review will be disseminated through peer‐reviewed publication. With the review, we hope to inform future randomised clinical trials and improve clinical practice. John Wiley and Sons Inc. 2022-11-12 2023-02 /pmc/articles/PMC10099998/ /pubmed/36310523 http://dx.doi.org/10.1111/aas.14166 Text en © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Articles
Fenger, Anne‐Sophie Worm
Olsen, Markus Harboe
Fabritius, Maria Louise
Riberholt, Christian Gunge
Møller, Kirsten
Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title_full Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title_fullStr Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title_full_unstemmed Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title_short Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review
title_sort glycaemic control for patients with severe acute brain injury: protocol for a systematic review
topic Special Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099998/
https://www.ncbi.nlm.nih.gov/pubmed/36310523
http://dx.doi.org/10.1111/aas.14166
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