Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

There is a growing medical interest in combining several agents and optimizing their dosing schedules in a single trial in order to optimize the treatment for patients. Evaluating at doses of several drugs and their scheduling in a single Phase I trial simultaneously possess a number of statistical...

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Detalles Bibliográficos
Autores principales: Mozgunov, Pavel, Jaki, Thomas, Gounaris, Ioannis, Goddemeier, Thomas, Victor, Anja, Grinberg, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100035/
https://www.ncbi.nlm.nih.gov/pubmed/36428217
http://dx.doi.org/10.1002/sim.9594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100035/
https://www.ncbi.nlm.nih.gov/pubmed/36428217
http://dx.doi.org/10.1002/sim.9594

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