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Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial
There is a growing medical interest in combining several agents and optimizing their dosing schedules in a single trial in order to optimize the treatment for patients. Evaluating at doses of several drugs and their scheduling in a single Phase I trial simultaneously possess a number of statistical...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100035/ https://www.ncbi.nlm.nih.gov/pubmed/36428217 http://dx.doi.org/10.1002/sim.9594 |