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Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis
BACKGROUND: Our primary objective was to explore the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in acute pancreatitis (AP) admission to intensive care units. METHODS: This study is a retrospective cohort analysis based on the Medical Information Mart for...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100061/ https://www.ncbi.nlm.nih.gov/pubmed/37055750 http://dx.doi.org/10.1186/s12871-023-02074-4 |
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author | Gong, Fang Zhou, Quan Gui, Chunmei Huang, Shaohua |
author_facet | Gong, Fang Zhou, Quan Gui, Chunmei Huang, Shaohua |
author_sort | Gong, Fang |
collection | PubMed |
description | BACKGROUND: Our primary objective was to explore the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in acute pancreatitis (AP) admission to intensive care units. METHODS: This study is a retrospective cohort analysis based on the Medical Information Mart for Intensive Care III database. The eGFR was calculated based on Chronic Kidney Disease Epidemiology Collaboration equation. Cox models with restricted cubic spline functions were used to evaluated the association of eGFR with all-cause mortality. RESULTS: The mean eGFR was 65.93 ± 38.56 ml/min/1.73 m(2) in 493 eligible patients. 28-day mortality was 11.97% (59/ 493), which decreased by 15% with every 10 ml/min/1.73 m(2) increase in eGFR. The adjusted hazard ratio (95% confidence interval) was 0.85 (0.76–0.96). A non-linear association was proved between eGFR and all-cause mortality. When eGFR < 57 ml/min/1.73 m(2), there was a negative correlation between eGFR and 28-day mortality, hazard ratio (95% CI) was 0.97 (0.95, 0.99). The eGFR was also negatively correlated with in-hospital and in-ICU mortality. Subgroup analysis confirmed that the association between eGFR and 28-day mortality in different characteristics was stable. CONCLUSIONS: The eGFR was negatively correlated with all-cause mortality in AP when eGFR is less than the threshold inflection point. |
format | Online Article Text |
id | pubmed-10100061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101000612023-04-14 Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis Gong, Fang Zhou, Quan Gui, Chunmei Huang, Shaohua BMC Anesthesiol Research Article BACKGROUND: Our primary objective was to explore the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in acute pancreatitis (AP) admission to intensive care units. METHODS: This study is a retrospective cohort analysis based on the Medical Information Mart for Intensive Care III database. The eGFR was calculated based on Chronic Kidney Disease Epidemiology Collaboration equation. Cox models with restricted cubic spline functions were used to evaluated the association of eGFR with all-cause mortality. RESULTS: The mean eGFR was 65.93 ± 38.56 ml/min/1.73 m(2) in 493 eligible patients. 28-day mortality was 11.97% (59/ 493), which decreased by 15% with every 10 ml/min/1.73 m(2) increase in eGFR. The adjusted hazard ratio (95% confidence interval) was 0.85 (0.76–0.96). A non-linear association was proved between eGFR and all-cause mortality. When eGFR < 57 ml/min/1.73 m(2), there was a negative correlation between eGFR and 28-day mortality, hazard ratio (95% CI) was 0.97 (0.95, 0.99). The eGFR was also negatively correlated with in-hospital and in-ICU mortality. Subgroup analysis confirmed that the association between eGFR and 28-day mortality in different characteristics was stable. CONCLUSIONS: The eGFR was negatively correlated with all-cause mortality in AP when eGFR is less than the threshold inflection point. BioMed Central 2023-04-13 /pmc/articles/PMC10100061/ /pubmed/37055750 http://dx.doi.org/10.1186/s12871-023-02074-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Gong, Fang Zhou, Quan Gui, Chunmei Huang, Shaohua Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title | Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title_full | Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title_fullStr | Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title_full_unstemmed | Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title_short | Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
title_sort | association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100061/ https://www.ncbi.nlm.nih.gov/pubmed/37055750 http://dx.doi.org/10.1186/s12871-023-02074-4 |
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