Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis–Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes

Chronic intraperitoneal injection of thioacetamide (TAA) in rats has been used as an animal model of human cirrhosis to study the effects of the disease on drug metabolism. However, TAA inhibits P450 enzymes directly and independently of cirrhosis. We investigated the effects of chronic cirrhosis in...

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Detalles Bibliográficos
Autores principales: Chandrashekar, Devaraj Venkatapura, DuBois, Barent N., Rashid, Mamunur, Mehvar, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100077/
https://www.ncbi.nlm.nih.gov/pubmed/36370118
http://dx.doi.org/10.1111/bcpt.13813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100077/
https://www.ncbi.nlm.nih.gov/pubmed/36370118
http://dx.doi.org/10.1111/bcpt.13813

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