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In Situ Quench Reactions of Enantioenriched Secondary Alkyllithium Reagents in Batch and Continuous Flow Using an I/Li‐Exchange

We report a practical in situ quench (ISQ) procedure involving the generation of chiral secondary alkyllithiums from secondary alkyl iodides (including functionalized iodides bearing an ester or a nitrile) in the presence of various electrophiles such as aldehydes, ketones, Weinreb amides, isocyanat...

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Detalles Bibliográficos
Autores principales:	Kremsmair, Alexander, Wilke, Henrik R., Harenberg, Johannes H., Bissinger, Benjamin R. G., Simon, Matthias M., Alandini, Nurtalya, Knochel, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100098/ https://www.ncbi.nlm.nih.gov/pubmed/36269064 http://dx.doi.org/10.1002/anie.202214377

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