Cargando…
Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with s...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100099/ https://www.ncbi.nlm.nih.gov/pubmed/36437671 http://dx.doi.org/10.1111/ina.13165 |
_version_ | 1785025203525386240 |
---|---|
author | Oksanen, Lotta Auvinen, Mikko Kuula, Joel Malmgren, Rasmus Romantschuk, Martin Hyvärinen, Antti Laitinen, Sirpa Maunula, Leena Sanmark, Enni Geneid, Ahmed Sofieva, Svetlana Salokas, Julija Veskiväli, Helin Sironen, Tarja Grönholm, Tiia Hellsten, Antti Atanasova, Nina |
author_facet | Oksanen, Lotta Auvinen, Mikko Kuula, Joel Malmgren, Rasmus Romantschuk, Martin Hyvärinen, Antti Laitinen, Sirpa Maunula, Leena Sanmark, Enni Geneid, Ahmed Sofieva, Svetlana Salokas, Julija Veskiväli, Helin Sironen, Tarja Grönholm, Tiia Hellsten, Antti Atanasova, Nina |
author_sort | Oksanen, Lotta |
collection | PubMed |
description | COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with several methods. The aerosol dispersion was modeled by using the Large‐Eddy Simulation (LES) technique. Three risk‐reduction strategies were studied: (1) augmenting ventilation with air purifiers, (2) spatial partitioning with dividers, and (3) combination of 1 and 2. In all simulations infectious viruses were detected throughout the space proving the existence long‐distance aerosol transmission indoors. Experimental cumulative virus numbers and LES dispersion results were qualitatively similar. The LES results were further utilized to derive the evolution of infection probability. Air purifiers augmenting the effective ventilation rate by 65% reduced the spatially averaged infection probability by 30%–32%. This relative reduction manifests with approximately 15 min lag as aerosol dispersion only gradually reaches the purifier units. Both viral findings and LES results confirm that spatial partitioning has a negligible effect on the mean infection‐probability indoors, but may affect the local levels adversely. Exploitation of high‐resolution LES jointly with microbiological measurements enables an informative interpretation of the experimental results and facilitates a more complete risk assessment. |
format | Online Article Text |
id | pubmed-10100099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101000992023-04-14 Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant Oksanen, Lotta Auvinen, Mikko Kuula, Joel Malmgren, Rasmus Romantschuk, Martin Hyvärinen, Antti Laitinen, Sirpa Maunula, Leena Sanmark, Enni Geneid, Ahmed Sofieva, Svetlana Salokas, Julija Veskiväli, Helin Sironen, Tarja Grönholm, Tiia Hellsten, Antti Atanasova, Nina Indoor Air Original Articles COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with several methods. The aerosol dispersion was modeled by using the Large‐Eddy Simulation (LES) technique. Three risk‐reduction strategies were studied: (1) augmenting ventilation with air purifiers, (2) spatial partitioning with dividers, and (3) combination of 1 and 2. In all simulations infectious viruses were detected throughout the space proving the existence long‐distance aerosol transmission indoors. Experimental cumulative virus numbers and LES dispersion results were qualitatively similar. The LES results were further utilized to derive the evolution of infection probability. Air purifiers augmenting the effective ventilation rate by 65% reduced the spatially averaged infection probability by 30%–32%. This relative reduction manifests with approximately 15 min lag as aerosol dispersion only gradually reaches the purifier units. Both viral findings and LES results confirm that spatial partitioning has a negligible effect on the mean infection‐probability indoors, but may affect the local levels adversely. Exploitation of high‐resolution LES jointly with microbiological measurements enables an informative interpretation of the experimental results and facilitates a more complete risk assessment. John Wiley and Sons Inc. 2022-11-27 2022-11 /pmc/articles/PMC10100099/ /pubmed/36437671 http://dx.doi.org/10.1111/ina.13165 Text en © 2022 The Authors. Indoor Air published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Oksanen, Lotta Auvinen, Mikko Kuula, Joel Malmgren, Rasmus Romantschuk, Martin Hyvärinen, Antti Laitinen, Sirpa Maunula, Leena Sanmark, Enni Geneid, Ahmed Sofieva, Svetlana Salokas, Julija Veskiväli, Helin Sironen, Tarja Grönholm, Tiia Hellsten, Antti Atanasova, Nina Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title | Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title_full | Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title_fullStr | Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title_full_unstemmed | Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title_short | Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant |
title_sort | combining phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of sars‐cov‐2 in a restaurant |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100099/ https://www.ncbi.nlm.nih.gov/pubmed/36437671 http://dx.doi.org/10.1111/ina.13165 |
work_keys_str_mv | AT oksanenlotta combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT auvinenmikko combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT kuulajoel combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT malmgrenrasmus combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT romantschukmartin combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT hyvarinenantti combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT laitinensirpa combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT maunulaleena combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT sanmarkenni combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT geneidahmed combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT sofievasvetlana combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT salokasjulija combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT veskivalihelin combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT sironentarja combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT gronholmtiia combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT hellstenantti combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant AT atanasovanina combiningphi6asasurrogatevirusandcomputationallargeeddysimulationstostudyairbornetransmissionofsarscov2inarestaurant |