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Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant

COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with s...

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Autores principales: Oksanen, Lotta, Auvinen, Mikko, Kuula, Joel, Malmgren, Rasmus, Romantschuk, Martin, Hyvärinen, Antti, Laitinen, Sirpa, Maunula, Leena, Sanmark, Enni, Geneid, Ahmed, Sofieva, Svetlana, Salokas, Julija, Veskiväli, Helin, Sironen, Tarja, Grönholm, Tiia, Hellsten, Antti, Atanasova, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100099/
https://www.ncbi.nlm.nih.gov/pubmed/36437671
http://dx.doi.org/10.1111/ina.13165
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author Oksanen, Lotta
Auvinen, Mikko
Kuula, Joel
Malmgren, Rasmus
Romantschuk, Martin
Hyvärinen, Antti
Laitinen, Sirpa
Maunula, Leena
Sanmark, Enni
Geneid, Ahmed
Sofieva, Svetlana
Salokas, Julija
Veskiväli, Helin
Sironen, Tarja
Grönholm, Tiia
Hellsten, Antti
Atanasova, Nina
author_facet Oksanen, Lotta
Auvinen, Mikko
Kuula, Joel
Malmgren, Rasmus
Romantschuk, Martin
Hyvärinen, Antti
Laitinen, Sirpa
Maunula, Leena
Sanmark, Enni
Geneid, Ahmed
Sofieva, Svetlana
Salokas, Julija
Veskiväli, Helin
Sironen, Tarja
Grönholm, Tiia
Hellsten, Antti
Atanasova, Nina
author_sort Oksanen, Lotta
collection PubMed
description COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with several methods. The aerosol dispersion was modeled by using the Large‐Eddy Simulation (LES) technique. Three risk‐reduction strategies were studied: (1) augmenting ventilation with air purifiers, (2) spatial partitioning with dividers, and (3) combination of 1 and 2. In all simulations infectious viruses were detected throughout the space proving the existence long‐distance aerosol transmission indoors. Experimental cumulative virus numbers and LES dispersion results were qualitatively similar. The LES results were further utilized to derive the evolution of infection probability. Air purifiers augmenting the effective ventilation rate by 65% reduced the spatially averaged infection probability by 30%–32%. This relative reduction manifests with approximately 15 min lag as aerosol dispersion only gradually reaches the purifier units. Both viral findings and LES results confirm that spatial partitioning has a negligible effect on the mean infection‐probability indoors, but may affect the local levels adversely. Exploitation of high‐resolution LES jointly with microbiological measurements enables an informative interpretation of the experimental results and facilitates a more complete risk assessment.
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spelling pubmed-101000992023-04-14 Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant Oksanen, Lotta Auvinen, Mikko Kuula, Joel Malmgren, Rasmus Romantschuk, Martin Hyvärinen, Antti Laitinen, Sirpa Maunula, Leena Sanmark, Enni Geneid, Ahmed Sofieva, Svetlana Salokas, Julija Veskiväli, Helin Sironen, Tarja Grönholm, Tiia Hellsten, Antti Atanasova, Nina Indoor Air Original Articles COVID‐19 has highlighted the need for indoor risk‐reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with several methods. The aerosol dispersion was modeled by using the Large‐Eddy Simulation (LES) technique. Three risk‐reduction strategies were studied: (1) augmenting ventilation with air purifiers, (2) spatial partitioning with dividers, and (3) combination of 1 and 2. In all simulations infectious viruses were detected throughout the space proving the existence long‐distance aerosol transmission indoors. Experimental cumulative virus numbers and LES dispersion results were qualitatively similar. The LES results were further utilized to derive the evolution of infection probability. Air purifiers augmenting the effective ventilation rate by 65% reduced the spatially averaged infection probability by 30%–32%. This relative reduction manifests with approximately 15 min lag as aerosol dispersion only gradually reaches the purifier units. Both viral findings and LES results confirm that spatial partitioning has a negligible effect on the mean infection‐probability indoors, but may affect the local levels adversely. Exploitation of high‐resolution LES jointly with microbiological measurements enables an informative interpretation of the experimental results and facilitates a more complete risk assessment. John Wiley and Sons Inc. 2022-11-27 2022-11 /pmc/articles/PMC10100099/ /pubmed/36437671 http://dx.doi.org/10.1111/ina.13165 Text en © 2022 The Authors. Indoor Air published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Oksanen, Lotta
Auvinen, Mikko
Kuula, Joel
Malmgren, Rasmus
Romantschuk, Martin
Hyvärinen, Antti
Laitinen, Sirpa
Maunula, Leena
Sanmark, Enni
Geneid, Ahmed
Sofieva, Svetlana
Salokas, Julija
Veskiväli, Helin
Sironen, Tarja
Grönholm, Tiia
Hellsten, Antti
Atanasova, Nina
Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title_full Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title_fullStr Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title_full_unstemmed Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title_short Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant
title_sort combining phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of sars‐cov‐2 in a restaurant
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100099/
https://www.ncbi.nlm.nih.gov/pubmed/36437671
http://dx.doi.org/10.1111/ina.13165
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