The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration

Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejec...

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Detalles Bibliográficos
Autores principales: Yang, Mei, Peng, Guang-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100447/
https://www.ncbi.nlm.nih.gov/pubmed/37046324
http://dx.doi.org/10.1186/s13287-023-03319-2
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author Yang, Mei
Peng, Guang-hua
author_facet Yang, Mei
Peng, Guang-hua
author_sort Yang, Mei
collection PubMed
description Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejection or tumour formation. The therapeutic effect of stem cell-derived EVs has been proven in many diseases. However, the molecular mechanism of stem cell-derived EVs in retinal repair and regeneration has not been fully clarified. In this review, we described the biological characteristics of stem cell-derived EVs, summarized the current research on stem cell-derived EV treatment in retinal repair and regeneration, and discussed the potential and challenges of stem cell-derived EVs in translational medicine.
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spelling pubmed-101004472023-04-14 The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration Yang, Mei Peng, Guang-hua Stem Cell Res Ther Review Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejection or tumour formation. The therapeutic effect of stem cell-derived EVs has been proven in many diseases. However, the molecular mechanism of stem cell-derived EVs in retinal repair and regeneration has not been fully clarified. In this review, we described the biological characteristics of stem cell-derived EVs, summarized the current research on stem cell-derived EV treatment in retinal repair and regeneration, and discussed the potential and challenges of stem cell-derived EVs in translational medicine. BioMed Central 2023-04-12 /pmc/articles/PMC10100447/ /pubmed/37046324 http://dx.doi.org/10.1186/s13287-023-03319-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Mei
Peng, Guang-hua
The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title_full The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title_fullStr The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title_full_unstemmed The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title_short The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
title_sort molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100447/
https://www.ncbi.nlm.nih.gov/pubmed/37046324
http://dx.doi.org/10.1186/s13287-023-03319-2
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