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Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor

Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve replacement. The develo...

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Detalles Bibliográficos
Autores principales:	Sylvester, Christopher B., Amirkhosravi, Farshad, Bortoletto, Angelina S., West, William J., Connell, Jennifer P., Grande-Allen, K. Jane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100588/ https://www.ncbi.nlm.nih.gov/pubmed/37063962 http://dx.doi.org/10.3389/fcvm.2023.1112965

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