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Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response

Human endogenous retroviruses (HERVs) comprise about 8.3% of the human genome and are capable of producing RNA molecules that can be sensed by pattern recognition receptors, leading to the activation of innate immune response pathways. The HERV-K (HML-2) subgroup is the youngest HERV clade with the...

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Detalles Bibliográficos
Autores principales: Russ, Eric, Mikhalkevich, Natallia, Iordanskiy, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100713/
https://www.ncbi.nlm.nih.gov/pubmed/36861980
http://dx.doi.org/10.1128/spectrum.04438-22