Network Analysis Reveals the Molecular Bases of Statin Pleiotropy That Vary with Genetic Background

Many approved drugs are pleiotropic: for example, statins, whose main cholesterol-lowering activity is complemented by anticancer and prodiabetogenic mechanisms involving poorly characterized genetic interaction networks. We investigated these using the Saccharomyces cerevisiae genetic model, where...

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Detalles Bibliográficos
Autores principales: del Rio Hernandez, Cintya E., Campbell, Lani J., Atkinson, Paul H., Munkacsi, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100750/
https://www.ncbi.nlm.nih.gov/pubmed/36946734
http://dx.doi.org/10.1128/spectrum.04148-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100750/
https://www.ncbi.nlm.nih.gov/pubmed/36946734
http://dx.doi.org/10.1128/spectrum.04148-22

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