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Network Analysis Reveals the Molecular Bases of Statin Pleiotropy That Vary with Genetic Background
Many approved drugs are pleiotropic: for example, statins, whose main cholesterol-lowering activity is complemented by anticancer and prodiabetogenic mechanisms involving poorly characterized genetic interaction networks. We investigated these using the Saccharomyces cerevisiae genetic model, where...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100750/ https://www.ncbi.nlm.nih.gov/pubmed/36946734 http://dx.doi.org/10.1128/spectrum.04148-22 |