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Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans

Based on the structural modification of SM21, xy12, a new pyrylium salt derivative with enhanced antifungal activities, was synthesized. The MICs (MIC(90)) of xy12 against Candida albicans ranged from 0.125 to 0.25 μg/mL, about 2-fold lower than those of SM21. In addition, xy12 inhibited hypha and b...

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Detalles Bibliográficos
Autores principales:	Lv, Quanzhen, Yan, Lan, Wang, Jinxin, Feng, Jia, Gao, Lu, Qiu, Lijuan, Chao, Wen, Qin, Yu-Lin, Jiang, Yuanying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100848/ https://www.ncbi.nlm.nih.gov/pubmed/36790175 http://dx.doi.org/10.1128/spectrum.03209-22

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