Cargando…

Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans

Based on the structural modification of SM21, xy12, a new pyrylium salt derivative with enhanced antifungal activities, was synthesized. The MICs (MIC(90)) of xy12 against Candida albicans ranged from 0.125 to 0.25 μg/mL, about 2-fold lower than those of SM21. In addition, xy12 inhibited hypha and b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Quanzhen, Yan, Lan, Wang, Jinxin, Feng, Jia, Gao, Lu, Qiu, Lijuan, Chao, Wen, Qin, Yu-Lin, Jiang, Yuanying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100848/ https://www.ncbi.nlm.nih.gov/pubmed/36790175 http://dx.doi.org/10.1128/spectrum.03209-22

Ejemplares similares

Design, Synthesis and Antifungal Evaluation of Novel Pyrylium Salt In Vitro and In Vivo
por: Zhang, Yue, et al.
Publicado: (2022)

The Importance of Vacuolar Ion Homeostasis and Trafficking in Hyphal Development and Virulence in Candida albicans
por: Lv, Quanzhen, et al.
Publicado: (2021)

11g, a Potent Antifungal Candidate, Enhances Candida albicans Immunogenicity by Unmasking β-Glucan in Fungal Cell Wall
por: Huang, Xin, et al.
Publicado: (2020)

Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms
por: Ma, Chaoyu, et al.
Publicado: (2015)

Application of the Mutant Libraries for Candida albicans Functional Genomics
por: Wang, Ruina, et al.
Publicado: (2022)

Design, Synthesis and Structure-Activity Relationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents by Disrupting Cell Wall
por: Ni, Tingjunhong, et al.
Publicado: (2023)

Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans
por: Liao, Zebin, et al.
Publicado: (2016)

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species
por: Whaley, Sarah G., et al.
Publicado: (2017)

2,5-[C(4)+C(2)] Ringtransformation of Pyrylium Salts with α-Sulfinylacetaldehydes
por: Bauer, Dominik, et al.
Publicado: (2023)

Potent Antifungal Activity of Penta-O-galloyl-β-d-Glucose against Drug-Resistant Candida albicans, Candida auris, and Other Non-albicans Candida Species
por: Marquez, Lewis, et al.
Publicado: (2023)

Isolation and characterization of potent antifungal strains of the Streptomyces violaceusniger clade active against Candida albicans
por: Kang, Min J., et al.
Publicado: (2009)

Incidence and Antifungal Susceptibility of Candida Albicans Infections
por: UNGUREANU, A., et al.
Publicado: (2016)

Assessment of Proteolysis by Pyrylium and Other Fluorogenic Reagents
por: Al-Essa, Mohamed K., et al.
Publicado: (2021)

Untargeted metabolomics to evaluate antifungal mechanism: a study of Cophinforma mamane and Candida albicans interaction
por: Triastuti, Asih, et al.
Publicado: (2023)

Continuous-Flow Synthesis of Pyrylium Tetrafluoroborates: Application to Synthesis of Katritzky Salts and Photoinduced Cationic RAFT Polymerization
por: Sambiagio, Carlo, et al.
Publicado: (2021)

Electron paramagnetic resonance spectroscopic studies of the electron transfer reaction of Hantzsch ester and a pyrylium salt
por: Sebők-Nagy, K., et al.
Publicado: (2018)

Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida
por: Mandras, Narcisa, et al.
Publicado: (2016)

In Vitro Antifungal Activity of Equol against Candida albicans
por: Lee, Jeong Ah, et al.
Publicado: (2010)

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles
por: Shinde, Ravikumar Bapurao, et al.
Publicado: (2013)

Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review
por: Qin, Yulin, et al.
Publicado: (2023)

Mechanism landscape in pyrylium induced organic afterglow systems
por: Wang, Guangming, et al.
Publicado: (2023)

Metabonomics on Candida albicans indicate the excessive H3K56ac is involved in the antifungal activity of Shikonin
por: Liao, ZeBin, et al.
Publicado: (2019)

An integrated transcriptomic and metabolomic approach to investigate the heterogeneous Candida albicans biofilm phenotype
por: Delaney, Christopher, et al.
Publicado: (2023)

Analysis of Biofilm-Related Genes and Antifungal Susceptibility Pattern of Vaginal Candida albicans and Non-Candida albicans Species
por: Mohammadi, Faezeh, et al.
Publicado: (2021)

The Bovhyaluronidase Azoximer (Longidaza(®)) Disrupts Candida albicans and Candida albicans-Bacterial Mixed Biofilms and Increases the Efficacy of Antifungals
por: Gatina, Alina, et al.
Publicado: (2022)

Effect of Nicotinamide Against Candida albicans
por: Xing, XinRui, et al.
Publicado: (2019)

Hsp21 Potentiates Antifungal Drug Tolerance in Candida albicans
por: Mayer, François L., et al.
Publicado: (2013)

Effects of Chitosan on Candida albicans: Conditions for Its Antifungal Activity
por: Peña, Antonio, et al.
Publicado: (2013)

High Virulence and Antifungal Resistance in Clinical Strains of Candida albicans
por: Monroy-Pérez, Eric, et al.
Publicado: (2016)

Antifungal Activity of Oleuropein against Candida albicans—The In Vitro Study
por: Zorić, Nataša, et al.
Publicado: (2016)

Antifungal Activity of Coumarin Against Candida albicans Is Related to Apoptosis
por: Jia, Chang, et al.
Publicado: (2019)

Photodynamic Antifungal Activity of Hypocrellin A Against Candida albicans
por: Yang, Yijia, et al.
Publicado: (2019)

Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans
por: Uddin, Wasim, et al.
Publicado: (2021)

Antifungal Properties of Hydrazine-Based Compounds against Candida albicans
por: Camaioni, Louis, et al.
Publicado: (2023)

Autophagy Alters the Susceptibility of Candida albicans Biofilms to Antifungal Agents
por: Shen, Jiadi, et al.
Publicado: (2023)

Antifungal effects of eugenol on Candida albicans adherence to denture polymers
por: Zanul Abidin, Zubaidah, et al.
Publicado: (2023)

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal
por: Costa-de-Oliveira, Sofia, et al.
Publicado: (2020)

Pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species
por: Ou, Huang-Tz, et al.
Publicado: (2017)

Virulence and in vitro antifungal susceptibility of Candida albicans and Candida catenulata from laying hens
por: Rhimi, Wafa, et al.
Publicado: (2020)

Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis
por: Ishida, Kelly, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_d0d699ndgigl3bq6fpigdvffa2