Cargando…

PorinPredict: In Silico Identification of OprD Loss from WGS Data for Improved Genotype-Phenotype Predictions of P. aeruginosa Carbapenem Resistance

The increasing integration of genomics into routine clinical diagnostics requires reliable computational tools to identify determinants of antimicrobial resistance (AMR) from whole-genome sequencing data. Here, we developed PorinPredict, a bioinformatic tool that predicts defects of the Pseudomonas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biggel, Michael, Johler, Sophia, Roloff, Tim, Tschudin-Sutter, Sarah, Bassetti, Stefano, Siegemund, Martin, Egli, Adrian, Stephan, Roger, Seth-Smith, Helena M. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100854/ https://www.ncbi.nlm.nih.gov/pubmed/36715510 http://dx.doi.org/10.1128/spectrum.03588-22

Ejemplares similares

Investigation of OprD Porin Protein Levels in Carbapenem-Resistant Pseudomonas aeruginosa Isolates
por: Agah Terzi, Huseyin, et al.
Publicado: (2015)

Role of the Outer Membrane Protein OprD(2) in Carbapenem-Resistance Mechanisms of Pseudomonas aeruginosa
por: Shen, Jilu, et al.
Publicado: (2015)

ISPpu22, a novel insertion sequence in the oprD porin gene of a carbapenem-resistant Pseudomonas aeruginosa isolate from a burn patient in Tehran, Iran
por: Kalantar-Neyestanaki, Davood, et al.
Publicado: (2015)

Insertional inactivation of oprD in carbapenem-resistant Pseudomonas aeruginosa strains isolated from burn patients in Tehran, Iran
por: Shariati, A., et al.
Publicado: (2017)

OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa
por: Ducret, Verena, et al.
Publicado: (2016)

First detection of insertion sequence element ISPa1328 in the oprD porin gene of an imipenem-resistant Pseudomonas aeruginosa isolate from an idiopathic pulmonary fibrosis patient in Marseille, France
por: Al-Bayssari, C., et al.
Publicado: (2015)

Multilocus sequence typing and variations in the oprD gene of Pseudomonas aeruginosa isolated from a hospital in China
por: Liu, Huiqin, et al.
Publicado: (2018)

Upstream region of OprD mutations in imipenem-resistant and imipenem-sensitive Pseudomonas isolates
por: Kiani, Masoumeh, et al.
Publicado: (2021)

Prevalence and antibiotic resistance of Pseudomonas aeruginosa in water samples in central Italy and molecular characterization of oprD in imipenem resistant isolates
por: Schiavano, Giuditta Fiorella, et al.
Publicado: (2017)

Factors Affecting the Folding of Pseudomonas aeruginosa OprF Porin into the One-Domain Open Conformer
por: Sugawara, Etsuko, et al.
Publicado: (2010)

1281. An Evaluation of Tebipenem In Vitro Activity Against a Panel of Pseudomonas aeruginosa Isolates with Efflux, AmpC, and OprD Mutations
por: VanScoy, Brian D, et al.
Publicado: (2021)

The novel outer membrane protein from OprD/Occ family is associated with hypervirulence of carbapenem resistant Acinetobacter baumannii ST2/KL22
por: Hua, Mingxi, et al.
Publicado: (2020)

Study on the resistance mechanism via outer membrane protein OprD2 and metal β-lactamase expression in the cell wall of Pseudomonas aeruginosa
por: Cai, Shuangqi, et al.
Publicado: (2016)

Overproduction of active efflux pump and variations of OprD dominate in imipenem-resistant Pseudomonas aeruginosa isolated from patients with bloodstream infections in Taiwan
por: Kao, Cheng-Yen, et al.
Publicado: (2016)

Analysis of Metallo-β-lactamases, oprD Mutation, and Multidrug Resistance of β-lactam Antibiotic-Resistant Strains of Pseudomonas aeruginosa Isolated from Southern China
por: Li, Fei, et al.
Publicado: (2020)

Occurrence of NDM-1 and VIM-2 Co-Producing Escherichia coli and OprD Alteration in Pseudomonas aeruginosa Isolated from Hospital Environment Samples in Northwestern Tunisia
por: Maaroufi, Raouaa, et al.
Publicado: (2021)

Accuracy of urine flow cytometry and urine test strip in predicting relevant bacteriuria in different patient populations
por: Gehringer, Christian, et al.
Publicado: (2021)

Interplay of OpdP Porin and Chromosomal Carbapenemases in the Determination of Carbapenem Resistance/Susceptibility in Pseudomonas aeruginosa
por: Atrissi, Jad, et al.
Publicado: (2021)

Porin Involvement in Cephalosporin and Carbapenem Resistance of Burkholderia pseudomallei
por: Aunkham, Anuwat, et al.
Publicado: (2014)

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa
por: Horna, Gertrudis, et al.
Publicado: (2018)

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa
por: Ude, Johanna, et al.
Publicado: (2021)

Risk factors for colistin-resistant Enterobacteriaceae in a low-endemicity setting for carbapenem resistance – a matched case–control study
por: Büchler, Andrea C, et al.
Publicado: (2018)

The Outer Membrane Proteins OmpA, CarO, and OprD of Acinetobacter baumannii Confer a Two-Pronged Defense in Facilitating Its Success as a Potent Human Pathogen
por: Uppalapati, Siva R., et al.
Publicado: (2020)

WGS to predict antibiotic MICs for Neisseria gonorrhoeae
por: Eyre, David W., et al.
Publicado: (2017)

Conserved OprF as a Selective Immunogen against Pseudomonas aeruginosa
por: Kazemi Moghaddam, Ehsan, et al.
Publicado: (2017)

Berberine Derivatives as Pseudomonas aeruginosa MexXY-OprM Inhibitors: Activity and In Silico Insights
por: Giorgini, Giorgia, et al.
Publicado: (2021)

First case of IMP-15-producing Pseudomonas aeruginosa in Switzerland: Challenging laboratory diagnosis using whole genome sequencing (WGS)
por: Goldenberger, Daniel, et al.
Publicado: (2020)

Nosocomial human parainfluenza virus type 3 outbreak in immunocompromised patients, and possible lessons from the SARS-CoV-2 pandemic
por: Gürtler, N., et al.
Publicado: (2022)

Mutations in nalc gene of Mex AB-OprM efflux pump in carbapenem resistant Pseudomonas aeruginosa isolated from burn wounds in Yazd, Iran
por: Tafti, Fatemeh Akhavan, et al.
Publicado: (2020)

Association of OprF mutant and disturbance of biofilm and pyocyanin virulence in pseudomonas aeruginosa
por: Bukhari, Sarah I., et al.
Publicado: (2020)

Protective Efficacy of the OprF/OprI/PcrV Recombinant Chimeric Protein Against Pseudomonas aeruginosa in the Burned BALB/c Mouse Model
por: Fakoor, Mohammad Hadi, et al.
Publicado: (2020)

Immunopotentiating properties of chimeric OprF-OprI-PopB protein against Pseudomonas aeruginosa PAO1 in the infected burned rat model
por: Sabzehali, Fattaneh, et al.
Publicado: (2022)

Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India
por: Choudhury, Debarati, et al.
Publicado: (2015)

Transition From PCR-Ribotyping to Whole Genome Sequencing Based Typing of Clostridioides difficile
por: Seth-Smith, Helena M. B., et al.
Publicado: (2021)

Elevated OPRD1 promoter methylation in Alzheimer’s disease patients
por: Ji, Huihui, et al.
Publicado: (2017)

Independent, external validation of clinical prediction rules for the identification of extended-spectrum β-lactamase-producing Enterobacterales, University Hospital Basel, Switzerland, January 2010 to December 2016
por: Vock, Isabelle, et al.
Publicado: (2020)

oprC Impairs Host Defense by Increasing the Quorum-Sensing-Mediated Virulence of Pseudomonas aeruginosa
por: Gao, Pan, et al.
Publicado: (2020)

Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposes
por: Mayeux, Géraldine, et al.
Publicado: (2021)

MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa
por: Ma, Miao, et al.
Publicado: (2021)

OprF functions as a latch to direct Outer Membrane Vesicle release in Pseudomonas aeruginosa
por: Mathur, Shrestha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lb6pm4s97apvkea3m0kilgbmmi