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Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort

BACKGROUND: Arterial calcification and stiffness are common in people with chronic kidney disease (CKD). Higher vitamin K status has been associated with less arterial calcification and stiffness in CKD in cross-sectional studies. OBJECTIVES: To determine the association of vitamin K status with cor...

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Autores principales: Shea, M. Kyla, Wang, Jifan, Barger, Kathryn, Weiner, Daniel E., Townsend, Raymond R., Feldman, Harold I., Rosas, Sylvia E., Chen, Jing, He, Jiang, Flack, John, Jaar, Bernard G., Kansal, Mayank, Booth, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100935/
https://www.ncbi.nlm.nih.gov/pubmed/37181121
http://dx.doi.org/10.1016/j.cdnut.2022.100008
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author Shea, M. Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E.
Townsend, Raymond R.
Feldman, Harold I.
Rosas, Sylvia E.
Chen, Jing
He, Jiang
Flack, John
Jaar, Bernard G.
Kansal, Mayank
Booth, Sarah L.
author_facet Shea, M. Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E.
Townsend, Raymond R.
Feldman, Harold I.
Rosas, Sylvia E.
Chen, Jing
He, Jiang
Flack, John
Jaar, Bernard G.
Kansal, Mayank
Booth, Sarah L.
author_sort Shea, M. Kyla
collection PubMed
description BACKGROUND: Arterial calcification and stiffness are common in people with chronic kidney disease (CKD). Higher vitamin K status has been associated with less arterial calcification and stiffness in CKD in cross-sectional studies. OBJECTIVES: To determine the association of vitamin K status with coronary artery calcium (CAC) and arterial stiffness [pulse wave velocity (PWV)] at baseline and over 2–4 follow-up years in adults with mild-to-moderate CKD. METHODS: Participants (n = 2722) were drawn from the well-characterized Chronic Renal Insufficiency Cohort. Two vitamin K status biomarkers, plasma phylloquinone and plasma dephospho-uncarboxylated matrix gla protein [(dp)ucMGP], were measured at baseline. CAC and PWV were measured at baseline and over 2–4 y of follow-up. Differences across vitamin K status categories in CAC prevalence, incidence, and progression (defined as ≥100 Agatston units/y increase) and PWV at baseline and over follow-up were evaluated using multivariable-adjusted generalized linear models. RESULTS: CAC prevalence, incidence, and progression did not differ across plasma phylloquinone categories. Moreover, CAC prevalence and incidence did not differ according to plasma (dp)ucMGP concentration. Compared with participants with the highest (dp)ucMGP (≥450 pmol/L), those in the middle category (300–449 pmol/L) had a 49% lower rate of CAC progression (incidence rate ratio: 0.51; 95% CI: 0.33, 0.78). However, CAC progression did not differ between those with the lowest (<300 pmol/L) and those with the highest plasma (dp)ucMGP concentration (incidence rate ratio: 0.82; 95% CI: 0.56, 1.19). Neither vitamin K status biomarker was associated with PWV at baseline or longitudinally. CONCLUSIONS: Vitamin K status was not consistently associated with CAC or PWV in adults with mild-to-moderate CKD.
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spelling pubmed-101009352023-05-10 Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Shea, M. Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E. Townsend, Raymond R. Feldman, Harold I. Rosas, Sylvia E. Chen, Jing He, Jiang Flack, John Jaar, Bernard G. Kansal, Mayank Booth, Sarah L. Curr Dev Nutr Original Research BACKGROUND: Arterial calcification and stiffness are common in people with chronic kidney disease (CKD). Higher vitamin K status has been associated with less arterial calcification and stiffness in CKD in cross-sectional studies. OBJECTIVES: To determine the association of vitamin K status with coronary artery calcium (CAC) and arterial stiffness [pulse wave velocity (PWV)] at baseline and over 2–4 follow-up years in adults with mild-to-moderate CKD. METHODS: Participants (n = 2722) were drawn from the well-characterized Chronic Renal Insufficiency Cohort. Two vitamin K status biomarkers, plasma phylloquinone and plasma dephospho-uncarboxylated matrix gla protein [(dp)ucMGP], were measured at baseline. CAC and PWV were measured at baseline and over 2–4 y of follow-up. Differences across vitamin K status categories in CAC prevalence, incidence, and progression (defined as ≥100 Agatston units/y increase) and PWV at baseline and over follow-up were evaluated using multivariable-adjusted generalized linear models. RESULTS: CAC prevalence, incidence, and progression did not differ across plasma phylloquinone categories. Moreover, CAC prevalence and incidence did not differ according to plasma (dp)ucMGP concentration. Compared with participants with the highest (dp)ucMGP (≥450 pmol/L), those in the middle category (300–449 pmol/L) had a 49% lower rate of CAC progression (incidence rate ratio: 0.51; 95% CI: 0.33, 0.78). However, CAC progression did not differ between those with the lowest (<300 pmol/L) and those with the highest plasma (dp)ucMGP concentration (incidence rate ratio: 0.82; 95% CI: 0.56, 1.19). Neither vitamin K status biomarker was associated with PWV at baseline or longitudinally. CONCLUSIONS: Vitamin K status was not consistently associated with CAC or PWV in adults with mild-to-moderate CKD. American Society for Nutrition 2022-12-23 /pmc/articles/PMC10100935/ /pubmed/37181121 http://dx.doi.org/10.1016/j.cdnut.2022.100008 Text en © 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Shea, M. Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E.
Townsend, Raymond R.
Feldman, Harold I.
Rosas, Sylvia E.
Chen, Jing
He, Jiang
Flack, John
Jaar, Bernard G.
Kansal, Mayank
Booth, Sarah L.
Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_full Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_fullStr Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_full_unstemmed Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_short Association of Vitamin K Status with Arterial Calcification and Stiffness in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_sort association of vitamin k status with arterial calcification and stiffness in chronic kidney disease: the chronic renal insufficiency cohort
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100935/
https://www.ncbi.nlm.nih.gov/pubmed/37181121
http://dx.doi.org/10.1016/j.cdnut.2022.100008
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