Cargando…
Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies
Infections by Gram-negative pathogens are usually difficult to manage due to the drug export by efflux pumps. With the evolution and horizontal transfer of efflux pumps, there is an urgent need to discover safe and effective efflux pump inhibitors. Here, we found that the natural compound berberine...
Autores principales: | Li, Ying, Ge, Xizhen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10100983/ https://www.ncbi.nlm.nih.gov/pubmed/36786641 http://dx.doi.org/10.1128/spectrum.03324-22 |
Ejemplares similares
-
Molecular Dynamics Investigation of MFS Efflux Pump MdfA Reveals an Intermediate State between Its Inward and Outward Conformations
por: Li, Ying, et al.
Publicado: (2022) -
Crystal structures of MdfA complexed with acetylcholine and inhibitor reserpine
por: Liu, Ming, et al.
Publicado: (2016) -
A Contribution of MdfA to Resistance to Fluoroquinolones in Shigella flexneri
por: Kim, Jun-Young, et al.
Publicado: (2011) -
Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition
por: Wu, Hsin-Hui, et al.
Publicado: (2019) -
Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels
por: Yardeni, Eliane H., et al.
Publicado: (2019)