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PRAME Expression in Mucosal Melanoma of the Head and Neck Region
PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRA...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101133/ https://www.ncbi.nlm.nih.gov/pubmed/36912431 http://dx.doi.org/10.1097/PAS.0000000000002032 |
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author | Ricci, Costantino Altavilla, Maria V. Corti, Barbara Pasquini, Ernesto Presutti, Livo Baietti, Anna M. Amorosa, Luca Balbi, Tiziana Baldovini, Chiara Ambrosi, Francesca Grillini, Marco D’Errico, Antonia Fiorentino, Michelangelo Foschini, Maria P. |
author_facet | Ricci, Costantino Altavilla, Maria V. Corti, Barbara Pasquini, Ernesto Presutti, Livo Baietti, Anna M. Amorosa, Luca Balbi, Tiziana Baldovini, Chiara Ambrosi, Francesca Grillini, Marco D’Errico, Antonia Fiorentino, Michelangelo Foschini, Maria P. |
author_sort | Ricci, Costantino |
collection | PubMed |
description | PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRAME stain on a retrospective case series of mucosal melanocytic tumors of the head and neck region to compare 3 different scores and evaluate the most reliable one in this diagnostic set. Immunohistochemical analysis for PRAME was performed in 54 benign and malignant mucosal melanocytic tumors of the head and neck region collected from 41 patients. The best-performing cutoff of PRAME-positive cells (nuclear stain) to differentiate benign and malignant mucosal melanocytic tumors of the head and neck region is that proposed by Raghavan and colleagues (<60%/≥60% of PRAME-positive cells), with 100% and 77.8% of benign lesions and malignant tumors respectively correctly identified. Applying this score, PRAME stain showed the best results (sensitivity, specificity, accuracy, and positive and negative predictive values) for the diagnosis of head and neck melanocytic tumors. However, a subset of PRAME-negative malignant tumors was identified, especially located in the palatal area (hard and soft palate). Finally, high PRAME expression (≥60%) was associated with specific sites (nasal cavity/nasal septum/turbinates nasopharynx, and the maxillary sinus), nodular histotype, and female sex. |
format | Online Article Text |
id | pubmed-10101133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101011332023-04-14 PRAME Expression in Mucosal Melanoma of the Head and Neck Region Ricci, Costantino Altavilla, Maria V. Corti, Barbara Pasquini, Ernesto Presutti, Livo Baietti, Anna M. Amorosa, Luca Balbi, Tiziana Baldovini, Chiara Ambrosi, Francesca Grillini, Marco D’Errico, Antonia Fiorentino, Michelangelo Foschini, Maria P. Am J Surg Pathol Original Articles PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRAME stain on a retrospective case series of mucosal melanocytic tumors of the head and neck region to compare 3 different scores and evaluate the most reliable one in this diagnostic set. Immunohistochemical analysis for PRAME was performed in 54 benign and malignant mucosal melanocytic tumors of the head and neck region collected from 41 patients. The best-performing cutoff of PRAME-positive cells (nuclear stain) to differentiate benign and malignant mucosal melanocytic tumors of the head and neck region is that proposed by Raghavan and colleagues (<60%/≥60% of PRAME-positive cells), with 100% and 77.8% of benign lesions and malignant tumors respectively correctly identified. Applying this score, PRAME stain showed the best results (sensitivity, specificity, accuracy, and positive and negative predictive values) for the diagnosis of head and neck melanocytic tumors. However, a subset of PRAME-negative malignant tumors was identified, especially located in the palatal area (hard and soft palate). Finally, high PRAME expression (≥60%) was associated with specific sites (nasal cavity/nasal septum/turbinates nasopharynx, and the maxillary sinus), nodular histotype, and female sex. Lippincott Williams & Wilkins 2023-05 2023-03-13 /pmc/articles/PMC10101133/ /pubmed/36912431 http://dx.doi.org/10.1097/PAS.0000000000002032 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Original Articles Ricci, Costantino Altavilla, Maria V. Corti, Barbara Pasquini, Ernesto Presutti, Livo Baietti, Anna M. Amorosa, Luca Balbi, Tiziana Baldovini, Chiara Ambrosi, Francesca Grillini, Marco D’Errico, Antonia Fiorentino, Michelangelo Foschini, Maria P. PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title | PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title_full | PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title_fullStr | PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title_full_unstemmed | PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title_short | PRAME Expression in Mucosal Melanoma of the Head and Neck Region |
title_sort | prame expression in mucosal melanoma of the head and neck region |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101133/ https://www.ncbi.nlm.nih.gov/pubmed/36912431 http://dx.doi.org/10.1097/PAS.0000000000002032 |
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