Cargando…

PRAME Expression in Mucosal Melanoma of the Head and Neck Region

PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRA...

Descripción completa

Detalles Bibliográficos
Autores principales: Ricci, Costantino, Altavilla, Maria V., Corti, Barbara, Pasquini, Ernesto, Presutti, Livo, Baietti, Anna M., Amorosa, Luca, Balbi, Tiziana, Baldovini, Chiara, Ambrosi, Francesca, Grillini, Marco, D’Errico, Antonia, Fiorentino, Michelangelo, Foschini, Maria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101133/
https://www.ncbi.nlm.nih.gov/pubmed/36912431
http://dx.doi.org/10.1097/PAS.0000000000002032
_version_ 1785025443997417472
author Ricci, Costantino
Altavilla, Maria V.
Corti, Barbara
Pasquini, Ernesto
Presutti, Livo
Baietti, Anna M.
Amorosa, Luca
Balbi, Tiziana
Baldovini, Chiara
Ambrosi, Francesca
Grillini, Marco
D’Errico, Antonia
Fiorentino, Michelangelo
Foschini, Maria P.
author_facet Ricci, Costantino
Altavilla, Maria V.
Corti, Barbara
Pasquini, Ernesto
Presutti, Livo
Baietti, Anna M.
Amorosa, Luca
Balbi, Tiziana
Baldovini, Chiara
Ambrosi, Francesca
Grillini, Marco
D’Errico, Antonia
Fiorentino, Michelangelo
Foschini, Maria P.
author_sort Ricci, Costantino
collection PubMed
description PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRAME stain on a retrospective case series of mucosal melanocytic tumors of the head and neck region to compare 3 different scores and evaluate the most reliable one in this diagnostic set. Immunohistochemical analysis for PRAME was performed in 54 benign and malignant mucosal melanocytic tumors of the head and neck region collected from 41 patients. The best-performing cutoff of PRAME-positive cells (nuclear stain) to differentiate benign and malignant mucosal melanocytic tumors of the head and neck region is that proposed by Raghavan and colleagues (<60%/≥60% of PRAME-positive cells), with 100% and 77.8% of benign lesions and malignant tumors respectively correctly identified. Applying this score, PRAME stain showed the best results (sensitivity, specificity, accuracy, and positive and negative predictive values) for the diagnosis of head and neck melanocytic tumors. However, a subset of PRAME-negative malignant tumors was identified, especially located in the palatal area (hard and soft palate). Finally, high PRAME expression (≥60%) was associated with specific sites (nasal cavity/nasal septum/turbinates nasopharynx, and the maxillary sinus), nodular histotype, and female sex.
format Online
Article
Text
id pubmed-10101133
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-101011332023-04-14 PRAME Expression in Mucosal Melanoma of the Head and Neck Region Ricci, Costantino Altavilla, Maria V. Corti, Barbara Pasquini, Ernesto Presutti, Livo Baietti, Anna M. Amorosa, Luca Balbi, Tiziana Baldovini, Chiara Ambrosi, Francesca Grillini, Marco D’Errico, Antonia Fiorentino, Michelangelo Foschini, Maria P. Am J Surg Pathol Original Articles PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRAME stain on a retrospective case series of mucosal melanocytic tumors of the head and neck region to compare 3 different scores and evaluate the most reliable one in this diagnostic set. Immunohistochemical analysis for PRAME was performed in 54 benign and malignant mucosal melanocytic tumors of the head and neck region collected from 41 patients. The best-performing cutoff of PRAME-positive cells (nuclear stain) to differentiate benign and malignant mucosal melanocytic tumors of the head and neck region is that proposed by Raghavan and colleagues (<60%/≥60% of PRAME-positive cells), with 100% and 77.8% of benign lesions and malignant tumors respectively correctly identified. Applying this score, PRAME stain showed the best results (sensitivity, specificity, accuracy, and positive and negative predictive values) for the diagnosis of head and neck melanocytic tumors. However, a subset of PRAME-negative malignant tumors was identified, especially located in the palatal area (hard and soft palate). Finally, high PRAME expression (≥60%) was associated with specific sites (nasal cavity/nasal septum/turbinates nasopharynx, and the maxillary sinus), nodular histotype, and female sex. Lippincott Williams & Wilkins 2023-05 2023-03-13 /pmc/articles/PMC10101133/ /pubmed/36912431 http://dx.doi.org/10.1097/PAS.0000000000002032 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Articles
Ricci, Costantino
Altavilla, Maria V.
Corti, Barbara
Pasquini, Ernesto
Presutti, Livo
Baietti, Anna M.
Amorosa, Luca
Balbi, Tiziana
Baldovini, Chiara
Ambrosi, Francesca
Grillini, Marco
D’Errico, Antonia
Fiorentino, Michelangelo
Foschini, Maria P.
PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title_full PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title_fullStr PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title_full_unstemmed PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title_short PRAME Expression in Mucosal Melanoma of the Head and Neck Region
title_sort prame expression in mucosal melanoma of the head and neck region
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101133/
https://www.ncbi.nlm.nih.gov/pubmed/36912431
http://dx.doi.org/10.1097/PAS.0000000000002032
work_keys_str_mv AT riccicostantino prameexpressioninmucosalmelanomaoftheheadandneckregion
AT altavillamariav prameexpressioninmucosalmelanomaoftheheadandneckregion
AT cortibarbara prameexpressioninmucosalmelanomaoftheheadandneckregion
AT pasquiniernesto prameexpressioninmucosalmelanomaoftheheadandneckregion
AT presuttilivo prameexpressioninmucosalmelanomaoftheheadandneckregion
AT baiettiannam prameexpressioninmucosalmelanomaoftheheadandneckregion
AT amorosaluca prameexpressioninmucosalmelanomaoftheheadandneckregion
AT balbitiziana prameexpressioninmucosalmelanomaoftheheadandneckregion
AT baldovinichiara prameexpressioninmucosalmelanomaoftheheadandneckregion
AT ambrosifrancesca prameexpressioninmucosalmelanomaoftheheadandneckregion
AT grillinimarco prameexpressioninmucosalmelanomaoftheheadandneckregion
AT derricoantonia prameexpressioninmucosalmelanomaoftheheadandneckregion
AT fiorentinomichelangelo prameexpressioninmucosalmelanomaoftheheadandneckregion
AT foschinimariap prameexpressioninmucosalmelanomaoftheheadandneckregion