A Disguising Fast-Growing Metachronous Melanoma and COVID-19

An unusual case of a 52-year-old female with two metachronous melanomas is presented. An atypical fast-growing nodular melanoma appeared 18 months after the complete excision of an in situ melanoma and one month afterward a SARS-CoV-2 infection. Intra-nodal melanocytic proliferations were identified...

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Detalles Bibliográficos
Autores principales: Avram, Alina, Scurtu, Lucian G, Costache, Mariana, Simionescu, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101186/
https://www.ncbi.nlm.nih.gov/pubmed/37065319
http://dx.doi.org/10.7759/cureus.36108
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author Avram, Alina
Scurtu, Lucian G
Costache, Mariana
Simionescu, Olga
author_facet Avram, Alina
Scurtu, Lucian G
Costache, Mariana
Simionescu, Olga
author_sort Avram, Alina
collection PubMed
description An unusual case of a 52-year-old female with two metachronous melanomas is presented. An atypical fast-growing nodular melanoma appeared 18 months after the complete excision of an in situ melanoma and one month afterward a SARS-CoV-2 infection. Intra-nodal melanocytic proliferations were identified during lymph node assessment, raising important diagnostic and prognostic concerns. No melanoma susceptibility genes were found. This case report raises the question about the COVID-19 immunosuppression effect on the tumor microenvironment and the oncogenic potential of SARS-CoV-2. It also highlights the importance of clinical follow-up in melanoma patients, which was significantly delayed during the COVID-19 pandemic.
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spelling pubmed-101011862023-04-14 A Disguising Fast-Growing Metachronous Melanoma and COVID-19 Avram, Alina Scurtu, Lucian G Costache, Mariana Simionescu, Olga Cureus Dermatology An unusual case of a 52-year-old female with two metachronous melanomas is presented. An atypical fast-growing nodular melanoma appeared 18 months after the complete excision of an in situ melanoma and one month afterward a SARS-CoV-2 infection. Intra-nodal melanocytic proliferations were identified during lymph node assessment, raising important diagnostic and prognostic concerns. No melanoma susceptibility genes were found. This case report raises the question about the COVID-19 immunosuppression effect on the tumor microenvironment and the oncogenic potential of SARS-CoV-2. It also highlights the importance of clinical follow-up in melanoma patients, which was significantly delayed during the COVID-19 pandemic. Cureus 2023-03-13 /pmc/articles/PMC10101186/ /pubmed/37065319 http://dx.doi.org/10.7759/cureus.36108 Text en Copyright © 2023, Avram et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Avram, Alina
Scurtu, Lucian G
Costache, Mariana
Simionescu, Olga
A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title_full A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title_fullStr A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title_full_unstemmed A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title_short A Disguising Fast-Growing Metachronous Melanoma and COVID-19
title_sort disguising fast-growing metachronous melanoma and covid-19
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101186/
https://www.ncbi.nlm.nih.gov/pubmed/37065319
http://dx.doi.org/10.7759/cureus.36108
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